Your Genomic Blueprint

Gene	SNP	Genotype	Effect
VEGFA	rs6552828	GG	VEGF - angiogenesis, VO2max trainability
VEGFA	rs2010963	CG	VEGF expression - capillary density
VEGFA	rs3025039	CC	VEGF 3' UTR - endurance response
VEGFA	rs833061	TT	VEGF promoter

Gene	SNP	Genotype	Status	Effect
ACTN3	rs1815739	CT	Carrier	R577X - XX = endurance, RR = power/sprint
PPARGC1A	rs8192678	TT	Typical	PGC-1alpha Gly482Ser - muscle metabolism

Gene	SNP	Genotype	Status	Effect
PPARD	rs2016520	TT	Typical	PPAR-delta - endurance capacity
ADRB3	rs4994	AA	Typical	Beta-3 receptor - fat burning
ADRB2	rs1042713	AG	Carrier	Beta-2 receptor - bronchodilation
ADRB2	rs1042714	CC	Typical	ADRB2 Gln27Glu - asthma/exercise
HIF1A	rs11549465	CC	Typical	Pro582Ser - oxygen sensing
NOS3	rs2070744	TT	Typical	eNOS promoter - nitric oxide
PPARA	rs1800206	CC	Significant	Fatty acid oxidation

Gene	SNP	Genotype	Status	Effect
AMPD1	rs17602729	GG	Typical	AMP deaminase - muscle energy
CNTF	rs1800169	AG	Carrier	Ciliary neurotrophic factor - muscle mass

Gene	SNP	Genotype	Status	Effect
VEGFA	rs6552828	GG	Significant	VEGF - angiogenesis, VO2max trainability
VEGFA	rs2010963	CG	Carrier	VEGF expression - capillary density
VEGFA	rs3025039	CC	Typical	VEGF 3' UTR - endurance response
VEGFA	rs833061	TT	Significant	VEGF promoter

Gene	SNP	Genotype	Status	Effect
IL6	rs1800795	GG	Typical	-174G>C - inflammation/recovery
TNF	rs1800629	GG	Typical	TNF-alpha - muscle damage response
IL10	rs1800896	TT	Typical	IL-10 - anti-inflammatory recovery
SOD2	rs4880	AG	Typical	MnSOD - oxidative stress from exercise
SOD1	rs2070424	AG	Carrier	Cu/Zn SOD - muscle recovery

Gene	SNP	Genotype	Status	Effect
COL5A1	rs12722	CC	Typical	Type V collagen - tendon/ligament strength
COL1A1	rs1800012	CC	Typical	Type I collagen - bone stress fractures
COL1A1	rs1107946	CC	Typical	Collagen I - ACL injury risk
GDF5	rs143383	GG	Typical	Growth differentiation factor - Achilles risk
COL12A1	rs970547	CC	Typical	Type XII collagen - anterior cruciate ligament
MMP3	rs679620	TT	Typical	MMP-3 - tendinopathy risk

Gene	SNP	Genotype	Status	Effect
CYP1A2	rs762551	AA	Typical	Caffeine metabolism - ergogenic effect
AHR	rs4410790	CC	Typical	Caffeine consumption tendency

Gene	SNP	Genotype	Status	Effect
COMT	rs4680	AG	Carrier	Val158Met - pain tolerance
SCN9A	rs6746030	GG	Typical	Nav1.7 sodium channel - pain sensitivity

Gene	SNP	Genotype	Status	Effect
SHBG	rs6258	CC	Typical	Sex hormone binding globulin - free testosterone
SHBG	rs1799941	GG	Typical	SHBG levels - testosterone availability
SHBG	rs12150660	GG	Typical	Free testosterone
CYP19A1	rs10046	AG	Typical	Aromatase - testosterone to estrogen

Gene	SNP	Genotype	Status	Effect
ADRB1	rs1801253	CG	Carrier	Beta-1 receptor - heart rate response

Gene	SNP	Genotype	Status	Effect
APOE	rs7412	CC	Typical	APOE - response to creatine
APOE	rs429358	TT	Typical	APOE ε4 - creatine/concussion risk

Test	Frequency	Target	Genetic Reason	Est. Cost
Homocysteine	Every 3 months	< 8 µmol/L	Monitor methylation protocol effectiveness Standard reference range is <15 µmol/L, but your MTHFR variant means methylation efficiency is reduced — tighter control at <8 is recommended to track supplement response.	Covered by most insurance
Methylmalonic Acid	Every 3 months	< 271 nmol/L	Functional B12 status — more reliable than serum B12 Serum B12 can appear normal even when tissue levels are low. MMA is the gold standard for detecting functional B12 deficiency.	Covered by most insurance; $30-50 if self-pay
Folate (RBC)	Every 3 months	> 400 ng/mL	Tissue folate level — tracks MTHFR supplementation RBC folate reflects 3-month tissue stores, not just recent intake. Target >400 is higher than standard (>140) because your MTHFR variant requires more folate for adequate methylation.	Covered by most insurance
Vitamin D (25-OH)	Every 3 months	50-80 ng/mL	VDR/GC variants — monitor response to 5000 IU dosing Standard sufficiency is >30 ng/mL, but your VDR and GC variants reduce vitamin D receptor efficiency — optimal function requires higher levels (50-80).	Covered by most insurance
Alpha-1 Antitrypsin Level	Once (baseline)	> 100 mg/dL	SERPINA1 PiSS — confirm AAT protein level One-time test to confirm whether your SERPINA1 variants translate to clinically low AAT protein. If low, lung function monitoring is recommended.	Covered by most insurance; may require prior authorization
HbA1c	Every 6 months	< 5.4%	T2D PRS 99.9th percentile — early detection priority Standard prediabetes threshold is 5.7%, but your 99.9th percentile T2D genetic risk warrants earlier intervention at 5.4% to catch trends before clinical prediabetes develops.	Covered by most insurance
Fasting Glucose + Insulin	Every 6 months	Glucose < 90, HOMA-IR < 1.5	Insulin resistance monitoring given T2D risk HOMA-IR combines glucose and insulin into a single insulin resistance score. Target <1.5 is stricter than standard (<2.5) given your extreme T2D genetic risk.	Covered by most insurance; insulin add-on $15-25 if not included
hs-CRP	Every 6 months	< 1.0 mg/L	Systemic inflammation marker — relevant for CAD risk Standard cardiovascular risk threshold is <3.0, but your CAD PRS 99.99th percentile means even mild inflammation compounds genetic risk — target <1.0.	Covered by most insurance
Lipid Panel (advanced)	Every 6 months	LDL-P < 1000, ApoB < 90	CAD PRS 99.99th — particle count more predictive than standard LDL Standard lipid panels miss particle count. ApoB and LDL-P are stronger predictors of cardiovascular events, especially important given your extreme CAD genetic risk.	$50-100 out of pocket; some insurers cover with cardiovascular risk documentation
Omega-3 Index	Every 6 months	> 8%	Verify EPA/DHA supplementation is reaching target given FADS1/2 block Your FADS1/2 variants prevent efficient ALA→EPA/DHA conversion. This test confirms your fish oil supplementation is actually raising blood levels.	$50-80 out of pocket; rarely covered by insurance
Magnesium RBC	Every 6 months	5.0-6.5 mg/dL	Serum Mg is unreliable — RBC level tracks tissue stores Only 1% of body magnesium is in serum — RBC magnesium reflects actual tissue status and tracks supplementation response.	$30-50 out of pocket; some labs bundle with mineral panels
Liver Panel (ALT, AST, GGT)	Every 6 months	ALT < 25 U/L	Monitor supplement load on liver; baseline for NAC therapy Target ALT <25 is stricter than standard (<40) based on research showing optimal liver function at lower thresholds. Monitors multiple supplement safety.	Covered by most insurance
Thyroid Panel (TSH, fT3, fT4)	Annually	TSH 1.0-2.5	DIO1/DIO2 variants — verify T4-to-T3 conversion Standard TSH range is 0.4-4.5, but your DIO variants may impair T4→T3 conversion. A TSH in the 1.0-2.5 range with adequate fT3 confirms normal thyroid function.	Covered by most insurance
CoQ10 (plasma)	Annually	> 2.5 µg/mL	Verify supplementation adequacy Confirms your 200mg daily ubiquinol is reaching therapeutic levels. Sub-therapeutic levels suggest absorption issues.	$40-80 out of pocket; specialty test
Iron Studies (ferritin, TIBC)	Annually	Ferritin 50-150 ng/mL	Baseline metabolic panel Standard ferritin range is 12-300, but optimal is 50-150. Too low causes fatigue; too high indicates iron overload or inflammation.	Covered by most insurance

Complete Genetic Reference

Every variant analyzed — 1007 findings, 518 traits, 166 drug-gene interactions

For clinical use: This section contains the complete raw genetic analysis output. Share with a geneticist or genetic counselor for detailed interpretation. Findings are grouped by body system and sorted by risk significance. Click any section header to expand.

All Clinical Findings

1007 findings across 18 categories, sorted by risk

1007

Eyes, Ears & Skin 123 38 risk

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Gene	rsID	Genotype	Severity	Risk	Description
LCT	rs4988235	GG	moderate	2	Lactose intolerance - calcium impact
RANKL	rs9594738	CC	moderate	2	Osteoclast activation
C3	rs2230199	GG	moderate	2	Complement C3
LOXL1	rs3825942	GG	moderate	2	Exfoliation glaucoma
GJD2	rs524952	AA	moderate	2	Gap junction - eye growth
HERC2	rs12913832	AA	moderate	2	OCA2 regulation - blue eyes
PCDH15	rs7598759	TT	moderate	2	Protocadherin - hair cell function
CYP1A2	rs4646316	CC	moderate	2	Drug metabolism
SCN10A	rs6795970	AA	moderate	2	Sodium channel - PR interval
TRPV1	rs8065080	TT	moderate	2	Capsaicin receptor
COL5A1	rs12722	CC	moderate	2	COL5A1 - Achilles tendinopathy
TGFBR2	rs2118181	TT	moderate	2	TGF-beta receptor II
SMAD3	rs10492367	GG	moderate	2	SMAD3 - OA susceptibility
LBX1	rs11190870	TT	moderate	2	LBX1 - adolescent scoliosis
C3	rs2230199	GG	moderate	2	Complement C3 - joint
ERAP1	rs27434	GG	moderate	2	ERAP1 - peptide processing
SLC2A9	rs734553	TT	moderate	2	SLC2A9 - gout susceptibility
TNC	rs240736	AA	moderate	2	Tenascin-C - tendon injury
MMP3	rs679620	TT	moderate	2	MMP3 - tendon matrix
ESR1	rs2234693	CT	low	1	Bone maintenance via estrogen
ESR1	rs9340799	AG	low	1	Estrogen signaling in bone
C2	rs9332739	CG	low	1	Complement pathway
CAV1/CAV2	rs4236601	AG	low	1	Intraocular pressure regulation
VEGFA	rs2010963	CG	low	1	VEGF - retinal blood vessels
SOD1	rs2070424	AG	low	1	Superoxide dismutase - protects cochlea
NOS1AP	rs10494366	GT	low	1	Long QT risk with certain drugs
PITX2	rs10033464	GT	low	1	Cardiac development
COMT	rs4680	AG	low	1	Met allele - higher pain sensitivity
MTDH	rs1835740	CT	low	1	Glutamate signaling
TGFB1	rs1800469	AG	low	1	TGF-beta1 - fibrosis/connective
DIO2	rs225014	CT	low	1	DIO2 - OA progression
ASPN	rs6976	CT	low	1	Asporin - OA susceptibility
FTO	rs8044769	CT	low	1	FTO - OA/obesity link
TNFRSF11B	rs4355801	AG	low	1	OPG - osteoprotegerin
ESR1	rs2234693	CT	low	1	Estrogen receptor alpha - BMD
ESR1	rs9340799	AG	low	1	ESR1 XbaI - fracture risk
MEPE	rs2504063	AG	low	1	MEPE - bone mineralization
AGTR2	rs11091046	A	low	1	AGTR2 - angiotensin receptor / gestational duration
GC (DBP)	rs2282679	TT	low	0	Lower vitamin D levels - bone impact
GC	rs7041	CC	low	0	Reduced vitamin D binding
LRP5	rs3736228	CC	low	0	Wnt signaling - critical for bone
CALCR	rs1801197	AG	low	0	Bone resorption regulation
TNFRSF11B	rs2707466	TT	low	0	Bone turnover marker
TNFRSF11B	rs3102735	TT	low	0	Bone remodeling
COL1A1	rs1800012	CC	low	0	Sp1 binding site - fracture risk
COL1A1	rs1107946	CC	low	0	Collagen formation
CASR	rs1801725	GG	low	0	Calcium homeostasis
CASR	rs1042636	AA	low	0	PTH regulation
VKORC1	rs9923231	CC	low	0	Osteocalcin activation
GPATCH1	rs6696981	GT	low	0	Bone mineral density GWAS hit
CFH	rs1061170	TT	low	0	Complement factor H - major AMD gene
ARMS2	rs10490924	GG	low	0	Second major AMD risk gene
HTRA1	rs11200638	GG	low	0	Serine protease - AMD risk
CFB	rs641153	GG	low	0	Complement factor B
SIX6	rs10483727	TT	low	0	Optic nerve development
LOXL1	rs2165241	CC	low	0	Lysyl oxidase - pseudoexfoliation
LOXL1	rs1048661	TT	low	0	Major exfoliation gene
TMCO1	rs4656461	AA	low	0	Transmembrane protein
LAMA2	rs12193446	AA	low	0	Laminin - eye structure
BMP2	rs4373767	TT	low	0	Bone morphogenic protein - eye growth
SHISA6	rs2969180	GG	low	0	Eye development
EPO	rs1617640	AA	low	0	Erythropoietin - retinal neovascularization
OCA2	rs1800407	CC	low	0	Eye pigmentation
GJB2	rs72474224	CC	low	0	35delG equivalent
GJB6	rs2274084	CC	low	0	Related to GJB2 hearing loss
NAT2	rs1799930	GG	low	0	Slow acetylator - drug toxicity
MT-RNR1	rs267606617	A	low	0	Mitochondrial - gentamicin deafness
SLCO1B1	rs4149056	TT	low	0	Drug transporter - ototoxic drug handling
VDR	rs2228570	AG	low	0	Vitamin D receptor - auditory
TGFB1	rs39399	GG	low	0	TGF-beta - bone remodeling in ear
TGFB1	rs1800472	GG	low	0	Bone overgrowth in middle ear
ZNF804A	rs1344706	AA	low	0	Neural connectivity - hearing processing
NOS1AP	rs12143842	CC	low	0	Nitric oxide - cardiac repolarization
KCNH2	rs2074238	CC	low	0	HERG potassium channel
SCN5A	rs1805124	TT	low	0	Cardiac sodium channel
PITX2	rs2200733	CC	low	0	AF major risk locus
SCN1A	rs3812718	TT	low	0	Sodium channel - seizure threshold
SCN1A	rs2298771	TT	low	0	Febrile seizure risk
SCN2A	rs11891634	CC	low	0	Neuronal sodium channel
SCN9A	rs6746030	GG	low	0	Nav1.7 - pain perception
OPRM1	rs1799971	AA	low	0	Mu opioid receptor - reduced response
KCNJ2	rs4726443	CC	low	0	Inward rectifier potassium
IL8	rs4073	TT	low	0	Inflammation marker
CACNA1C	rs1006737	GG	low	0	L-type calcium channel
CLCN1	rs2070106	GG	low	0	Muscle chloride channel
COL3A1	rs1800255	GG	low	0	Collagen III - vascular EDS marker
COL1A1	rs1107946	CC	low	0	Collagen I - hypermobility
TNXB	rs2075555	GG	low	0	Tenascin-X - hypermobile EDS
COL1A1	rs1800012	CC	low	0	COL1A1 - tissue laxity
VDR	rs1544410	CT	low	0	Vitamin D receptor - bone density
GDF5	rs143383	GG	low	0	GDF5 - major OA locus
COL11A1	rs3815148	AA	low	0	Collagen XI - hip OA
COMP	rs11177	AG	low	0	COMP - cartilage oligomeric
LRP5	rs3736228	CC	low	0	LRP5 - bone mineral density
TNFRSF11B	rs3102735	TT	low	0	OPG - bone resorption
RANKL	rs9594759	CC	low	0	RANKL - osteoclast activation
VDR	rs731236	AA	low	0	VDR TaqI - calcium metabolism
SOST	rs1566045	TT	low	0	SOST - BMD
BNC2	rs6137473	AG	low	0	BNC2 - scoliosis
PAX1	rs12946942	GG	low	0	PAX1 - spinal development
ERAP1	rs30187	CC	low	0	ERAP1 - AS in HLA-B27+
IL23R	rs11209026	GG	low	0	IL-23R - AS/SpA
PTPN22	rs2476601	GG	low	0	PTPN22 - RA major
HLA-DRB1	rs6910071	AA	low	0	HLA-DRB1 shared epitope
ABCG2	rs2231142	GG	low	0	ABCG2 Q141K - uric acid
SLC2A9	rs16890979	CC	low	0	SLC2A9 - urate transport
SLC17A1	rs11942223	TT	low	0	SLC17A1 - uric acid
COL5A1		CC	low	0	COL5A1 - Achilles tendinopathy
TGFBR2		TT	low	0	TGF-beta receptor II
SMAD3		GG	low	0	SMAD3 - OA susceptibility
LBX1		TT	low	0	LBX1 - adolescent scoliosis
C3		GG	low	0	Complement C3 - joint
ERAP1		GG	low	0	ERAP1 - peptide processing
SLC2A9		TT	low	0	SLC2A9 - gout susceptibility
TNC		AA	low	0	Tenascin-C - tendon injury
MMP3		TT	low	0	MMP3 - tendon matrix
BACE2	rs6517656	GG	low	0	BACE2 - pregnancy glycemic trait
ITGB3	rs5918	TT	low	0	ITGB3/GPIIIa PlA2 - recurrent pregnancy loss
IL10	rs1800871	AG	low	0	IL-10 -819T - pregnancy immune tolerance
IL1B	rs1143634	GG	low	0	IL-1B +3954 - inflammatory miscarriage risk
TNF	rs361525	GG	low	0	TNF -238A - pregnancy inflammation
NQO1	rs1800566	GG	low	0	NQO1 P187S - oxidative stress / retinal
MT-RNR1	rs267606617	A	low	0	MT-RNR1 m.1555A>G - aminoglycoside hearing loss

Immune & Autoimmune 114 31 risk

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Gene	rsID	Genotype	Severity	Risk	Description
REL	rs13031237	GG	moderate	2	REL - NF-kB pathway, RA
HLA-DRB1	rs1270942	AA	moderate	2	HLA-DRB1 - lupus susceptibility
C8orf13	rs13277113	AA	moderate	2	BLK - B cell kinase, lupus
CD247	rs2056626	GG	moderate	2	CD247 - scleroderma susceptibility
STAT4	rs3821236	GG	moderate	2	STAT4 - systemic sclerosis
IRF8	rs11642873	AA	moderate	2	IRF8 - scleroderma risk
TSHR	rs4947296	TT	moderate	2	TSH receptor - Graves
ERAP1	rs27434	GG	moderate	2	ERAP1 - peptide processing, AS
IL23R	rs10889677	AA	moderate	2	IL-23R - autoimmune inflammation
IL18RAP	rs11805303	TT	moderate	2	IL-18RAP - autoimmune
HLA-DPA1	rs3077	AA	moderate	2	HLA-DPA1 - HBV clearance
C3	rs2230199	GG	moderate	2	Complement C3 - AMD/infection
CFI	rs10033900	TT	moderate	2	Factor I - complement regulation
TRAF1	rs3761847	AG	low	1	TRAF1-C5 - RA susceptibility
STAT4	rs10760130	AG	low	1	STAT4 - RA/lupus
IRF5	rs10954213	AG	low	1	IRF5 - interferon pathway, lupus
PXK	rs6445975	GT	low	1	PXK - lupus susceptibility
IRF5	rs4728142	AG	low	1	IRF5 - Sjögren's/lupus
STAT4	rs485497	AG	low	1	STAT4 - Sjögren's risk
CD28	rs1980422	CT	low	1	CD28 - Graves disease
PTPN22	rs4263037	AG	low	1	PTPN22 - myasthenia gravis
AIRE	rs2075876	AG	low	1	AIRE - thymic tolerance, MG
HLA-DPB1	rs9275572	AG	low	1	HLA-DP - granulomatosis
ABO	rs657152	AC	low	1	ABO - blood group A COVID risk
IFNAR2	rs2236757	AG	low	1	IFNAR2 - interferon/critical COVID
DPP9	rs12610495	AG	low	1	DPP9 - severe COVID GWAS
HLA-DPB1	rs9277535	AG	low	1	HLA-DPB1 - HBV chronicity
FUT2	rs601338	AG	low	1	FUT2 - non-secretor/norovirus resistance
IL7R	rs6897932	CT	low	1	IL-7R - T cell development/MS
TNFRSF1A	rs1800692	AG	low	1	TNFR1 - MS/autoinflammation
FUT2	rs601338	AG	low	1	FUT2 - secretor/Bifidobacterium/norovirus
HLA-DRB1	rs6910071	AA	low	0	HLA-DRB1 shared epitope - major RA risk
HLA-DRB1	rs660895	AA	low	0	HLA-DRB1*04 - RA susceptibility
PTPN22	rs2476601	GG	low	0	PTPN22 - T1D major locus
IL2RA	rs2104286	TT	low	0	CD25 - RA/T cell regulation
CTLA4	rs3087243	AA	low	0	CTLA4 - T cell checkpoint
STAT4	rs7574865	GG	low	0	STAT4 - lupus major locus
HLA-DQ	rs2187668	CC	low	0	HLA-DQ2.5 - lupus/celiac
IRF5	rs2070197	TT	low	0	IRF5 - SLE risk
IRF5	rs2004640	--	low	0	IRF5 splice - lupus
ITGAM	rs1143679	GG	low	0	CD11b - lupus nephritis
FAM167A	rs10488631	TT	low	0	BLK locus - lupus
PRDM1	rs548234	TT	low	0	BLIMP1 - B cell lupus
SH2B3	rs3184504	CC	low	0	SH2B3/LNK - Graves/Hashimoto
CTLA4	rs231775	AA	low	0	CTLA4 - thyroid autoimmunity
TSHR	rs179247	GG	low	0	TSHR - Graves susceptibility
FCRL3	rs12101261	CC	low	0	FCRL3 - autoimmune thyroid
NAA25	rs17696736	AA	low	0	NAA25/C12orf30 - T1D
ERBB3	rs11171739	TT	low	0	ERBB3 - T1D susceptibility
ERBB3	rs2292239	GG	low	0	ERBB3 - islet autoimmunity
IL2	rs2069762	AA	low	0	IL-2 - T1D susceptibility
HLA-DRA	rs3129889	AA	low	0	HLA-DR3/4 proxy - T1D
CTLA4	rs231770	CC	low	0	CTLA4 - MG susceptibility
TNF	rs1800629	GG	low	0	TNF-308 - ANCA vasculitis
ERAP1	rs30187	CC	low	0	ERAP1 - AS in HLA-B27+
IL23R	rs11209026	GG	low	0	IL-23R - AS protective if G
STAT4	rs10181656	CC	low	0	STAT4 - multiple autoimmune
IL12A	rs17810546	AA	low	0	IL-12A - autoimmune
IL12B	rs6887695	GG	low	0	IL-12B - psoriasis/autoimmune
REL		GG	low	0	REL - NF-kB pathway, RA
HLA-DRB1		AA	low	0	HLA-DRB1 - lupus susceptibility
C8orf13		AA	low	0	BLK - B cell kinase, lupus
CD247		GG	low	0	CD247 - scleroderma susceptibility
STAT4		GG	low	0	STAT4 - systemic sclerosis
IRF8		AA	low	0	IRF8 - scleroderma risk
TSHR		TT	low	0	TSH receptor - Graves
ERAP1		GG	low	0	ERAP1 - peptide processing, AS
IL23R		AA	low	0	IL-23R - autoimmune inflammation
IL18RAP		TT	low	0	IL-18RAP - autoimmune
CCR2	rs1799864	GG	low	0	CCR2 V64I - delayed AIDS progression
HCP5	rs2395029	TT	low	0	HCP5/HLA-B*57:01 - HIV control/abacavir
TRIM5	rs10838525	CC	low	0	TRIM5alpha - retroviral restriction
TLR4	rs4986790	AA	low	0	TLR4 D299G - TB/gram-negative
TLR4	rs4986791	CC	low	0	TLR4 T399I - TB susceptibility
VDR	rs2228570	AG	low	0	VDR FokI - TB susceptibility
TYK2	rs34536443	GG	low	0	TYK2 - impaired IFN/TB risk
G6PD	rs1050828	C	low	0	G6PD - malaria protection/hemolysis
DARC	rs2814778	TT	low	0	Duffy-negative - P. vivax resistance
ABO	rs8176719	--	low	0	Blood group O - malaria protection
ATP2B4	rs10900585	--	low	0	ATP2B4 - severe malaria GWAS
TMPRSS2	rs12329760	CC	low	0	TMPRSS2 - viral entry protease
IFNL3	rs12979860	--	low	0	IL28B - HCV treatment response
IFNL3	rs8099917	TT	low	0	IL28B - HCV clearance
SLC10A1	rs2296651	GG	low	0	NTCP - HBV receptor resistance
TLR3	rs3775290	CC	low	0	TLR3 - herpes encephalitis
MBL2	rs1800450	CC	low	0	MBL2 - mannose-binding lectin deficiency
NOD2	rs2066844	CC	low	0	NOD2 - Crohn's/mycobacterial
NOD2	rs2066845	GG	low	0	NOD2 - intracellular pathogen sensing
HLA-DPA1		AA	low	0	HLA-DPA1 - HBV clearance
CFH	rs1061170	TT	low	0	Factor H Y402H - AMD/aHUS
CFB	rs641153	GG	low	0	Factor B - AMD protection
MBL2	rs1800450	CC	low	0	MBL deficiency - recurrent infections
NKG2D	rs2255336	CT	low	0	NK cell activation - autoimmune
ERAP1	rs30187	CC	low	0	ERAP1 - peptide trimming/NK function
IL2RA	rs61839660	CC	low	0	CD25 - memory T cells/T1D
CTLA4	rs3087243	AA	low	0	CTLA4 - immune checkpoint/autoimmune
FOXP3	rs3761548	G	low	0	Foxp3 - regulatory T cells
STAT4	rs7574865	GG	low	0	STAT4 - Th1/SLE/RA
IL23R	rs11209026	GG	low	0	IL-23R - Th17/IBD/psoriasis
PTPN22	rs2476601	GG	low	0	PTPN22 - T cell signaling/autoimmune
LCT	rs4988235	GG	low	0	LCT - lactase/Bifidobacterium
ABO	rs8176719	--	low	0	ABO blood type - F. prausnitzii
NOD2	rs2066844	CC	low	0	NOD2 R702W - IBD/microbiome
NOD2	rs2066845	GG	low	0	NOD2 G908R - microbiome composition
NOD2	rs2066847	DD	low	0	NOD2 1007fs - Crohn's microbiome
CD209	rs4804803	AA	low	0	DC-SIGN - dendritic cell/pathogen
IL10	rs1800896	TT	low	0	IL-10 - anti-inflammatory/microbiome
CARD9	rs10870077	CG	low	0	CARD9 - innate/fungal microbiome
AOC1	rs10156191	CC	low	0	DAO - histamine clearance
HNMT	rs1050891	AA	low	0	HNMT - enzymatic activity
HRH1	rs2067474	GG	low	0	H1 receptor - allergy
HRH4	rs11665084	CC	low	0	H4 receptor - mast cell activation
C3		GG	low	0	Complement C3 - AMD/infection
CFI		TT	low	0	Factor I - complement regulation

Cardiovascular Health 110 32 risk

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Gene	rsID	Genotype	Severity	Risk	Description
MIA3	rs17465637	CC	moderate	2	MIA3 - coronary atherosclerosis
PHACTR1	rs12526453	CC	moderate	2	PHACTR1 - CAD, migraine link
2q36.3	rs2943634	CC	moderate	2	Early-onset MI risk
MTHFD1L	rs6922269	AA	moderate	2	Folate metabolism - MI risk
BAG3	rs2234962	TT	moderate	2	BAG3 - dilated cardiomyopathy
CAV1	rs3807989	AA	moderate	2	Caveolin 1 - AFib risk
PITX2	rs6817105	TT	moderate	2	PITX2 region - AFib
SCN10A	rs6795970	AA	moderate	2	SCN10A - cardiac conduction
EDN1	rs5370	TT	moderate	2	Endothelin-1 - vasoconstriction
EDN1	rs5370	TT	moderate	2	Endothelin-1 - vasoconstriction, BP
ATP2B1	rs2681472	AA	moderate	2	Calcium pump - BP regulation
CSK	rs1378942	CC	moderate	2	CSK - blood pressure
ZNF652	rs16948048	AA	moderate	2	ZNF652 - blood pressure
EDN1	rs5370	TT	moderate	2	Endothelin-1 - vasoconstriction, BP
ATP2B1	rs2681472	AA	moderate	2	Calcium pump - BP regulation
CSK	rs1378942	CC	moderate	2	CSK - blood pressure
ZNF652	rs16948048	AA	moderate	2	ZNF652 - blood pressure
SLC4A1	rs5036	TT	moderate	2	SLC4A1 - renal tubular acidosis / kidney stone
SLC22A3	rs9982601	CT	low	1	Organic cation transporter - MI
CXCL12	rs1746048	CT	low	1	Chemokine - MI susceptibility
LPL	rs320	GT	low	1	LPL - triglyceride clearance
APOA5	rs662799	AG	low	1	APOA5 - triglycerides
ADRB1	rs1801253	CG	low	1	Beta-1 receptor Arg389Gly - heart failure
PITX2	rs10033464	GT	low	1	PITX2 - AFib risk
NOS1AP	rs10494366	GT	low	1	NOS1AP - drug-induced QT prolongation
NINJ2	rs12425791	AG	low	1	Nerve injury induced protein - stroke
ADRB1	rs1801253	CG	low	1	Beta-1 receptor - BP response
ADRB2	rs1042713	AG	low	1	Beta-2 receptor - BP
PLCD3	rs12946454	AT	low	1	PLCD3 - hypertension
NPR3	rs1530440	CT	low	1	NPR3 - natriuretic peptide BP
FGF5	rs1458038	CT	low	1	FGF5 - blood pressure
FGF5	rs16998073	AT	low	1	FGF5 region - BP
9p21.3	rs1333049	GG	low	0	9p21 - major CAD risk locus
9p21.3	rs4977574	AA	low	0	9p21 - CAD/MI risk
9p21.3	rs10757274	AA	low	0	9p21 region - atherosclerosis
9p21.3	rs2383206	AA	low	0	CDKN2A/B - CAD risk
WDR12	rs6725887	TT	low	0	WDR12 - CAD susceptibility
COL4A1	rs4773144	AA	low	0	Collagen IV - vascular integrity
KIAA1462	rs2306374	TT	low	0	KIAA1462 - CAD locus
APOE	rs7412	CC	low	0	APOE ε2 - lower LDL (protective)
APOE	rs429358	TT	low	0	APOE ε4 - higher LDL, CVD risk
LIPC	rs1800588	CC	low	0	Hepatic lipase - HDL levels
LPL	rs328	CC	low	0	Lipoprotein lipase S447X - protective
PITX2	rs2200733	CC	low	0	PITX2 - major AFib locus
ZFHX3	rs2106261	CC	low	0	ZFHX3 - AFib susceptibility
KCNN3	rs7193343	CC	low	0	Small conductance K+ channel - AFib
KCNN3	rs13376333	CC	low	0	SK3 channel - AFib
GJA1	rs1448818	AC	low	0	Connexin 43 - cardiac conduction
NOS1AP	rs12143842	CC	low	0	NOS1AP - QT interval prolongation
SCN10A	rs846111	CC	low	0	Sodium channel - PR interval
TTN	rs10497520	CC	low	0	Titin - dilated cardiomyopathy
MYH7	rs3729989	TT	low	0	Beta-myosin heavy chain - HCM
COL3A1	rs1800255	GG	low	0	Collagen III - vascular EDS
DAB2IP	rs7025486	GG	low	0	DAB2IP - aortic aneurysm
9p21.3	rs10757278	AA	low	0	9p21 - abdominal aortic aneurysm
CHRNA3	rs1051730	GG	low	0	Nicotinic receptor - smoking/PAD link
ABO	rs1842993	TT	low	0	ABO blood type - VTE/stroke
CDKN1A	rs6599230	CT	low	0	Cell cycle - LV mass
NOS3	rs2070744	TT	low	0	eNOS promoter - NO production
IL10	rs1800896	TT	low	0	IL-10 - vascular inflammation
MIA3		CC	low	0	MIA3 - coronary atherosclerosis
PHACTR1		CC	low	0	PHACTR1 - CAD, migraine link
2q36.3		CC	low	0	Early-onset MI risk
MTHFD1L		AA	low	0	Folate metabolism - MI risk
BAG3		TT	low	0	BAG3 - dilated cardiomyopathy
CAV1		AA	low	0	Caveolin 1 - AFib risk
PITX2		TT	low	0	PITX2 region - AFib
SCN10A		AA	low	0	SCN10A - cardiac conduction
EDN1		TT	low	0	Endothelin-1 - vasoconstriction
9p21.3		GG	low	0
9p21.3		AA	low	0
9p21.3		AA	low	0
9p21.3		AA	low	0
WDR12		TT	low	0
COL4A1		AA	low	0
KIAA1462		TT	low	0
APOE		CC	low	0
APOE		TT	low	0
LIPC		CC	low	0
LPL		CC	low	0
PITX2		CC	low	0
ZFHX3		CC	low	0
KCNN3		CC	low	0
KCNN3		CC	low	0
GJA1		AC	low	0
NOS1AP		CC	low	0
SCN10A		CC	low	0
TTN		CC	low	0
MYH7		TT	low	0
COL3A1		GG	low	0
DAB2IP		GG	low	0
9p21.3		AA	low	0
CHRNA3		GG	low	0
ABO		TT	low	0
CDKN1A		CT	low	0
NOS3		TT	low	0
IL10		TT	low	0
AGT	rs699	AG	low	0	AGT M235T - hypertension
AGT	rs4762	GG	low	0	AGT T174M - blood pressure
AGTR1	rs5186	AA	low	0	AT1 receptor - hypertension
ADRB2	rs1042714	CC	low	0	ADRB2 Gln27Glu - hypertension
NOS3	rs2070744	TT	low	0	eNOS promoter - NO production
NT5C2	rs11191548	TT	low	0	NT5C2 - systolic BP
SH2B3	rs3184504	CC	low	0	LNK - hypertension
FGF5	rs2398162	AA	low	0	FGF5 - hypertension
SLC39A8	rs13107325	CC	low	0	Zinc transporter - BP
MTHFR	rs17367504	AA	low	0	MTHFR - BP/homocysteine
PLEKHA7	rs381815	CC	low	0	PLEKHA7 - hypertension
AGXT	rs34116584	CC	low	0	AGXT - primary hyperoxaluria type 1
SLC4A1		TT	low	0	SLC4A1 - renal tubular acidosis / kidney stone

Metabolism 107 33 risk

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Gene	rsID	Genotype	Severity	Risk	Description
PPARA	rs1800206	CC	moderate	2	Peroxisome proliferator - fatty acid oxidation
SDHD	rs11214077	AA	moderate	2	SDHD - paraganglioma type 1
TSHR	rs4947296	TT	moderate	2	TSH receptor - Graves disease
SLC22A12	rs505802	TT	moderate	2	URAT1 - urate reabsorption
TFR2	rs7385804	AA	moderate	2	TFR2 - hemochromatosis type 3
DNMT3A	rs2289195	GG	moderate	2	DNMT3A - CHIP/cardiovascular
DNMT3B	rs2424913	TT	moderate	2	DNMT3B - cancer/methylation
EZH2	rs3757441	TT	moderate	2	EZH2 - histone methyltransferase
TMEM18	rs6548238	CC	moderate	2	TMEM18 - early-onset obesity
GRB14	rs10195252	TT	moderate	2	GRB14 - waist-hip ratio
KCNJ11	rs5219	TT	moderate	2	KCNJ11 - potassium/diabetes
TMPRSS6	rs855791	GG	moderate	2	TMPRSS6 V736A - iron/hepcidin
SLC30A8	rs13266634	CC	moderate	2	ZnT8 - zinc/T2D beta-cell
CYP27A1	rs933994	TT	moderate	2	CYP27A1 - alternative 25-hydroxylase
MT-ND4L	rs2853826	A	low	1	Mitochondrial complex I
SOD1	rs2070424	AG	low	1	Cu/Zn superoxide dismutase
ACTN3	rs1815739	CT	low	1	R577X - sprint vs endurance
CDKN1B	rs2066827	GT	low	1	CDKN1B - MEN4/pituitary adenoma
RET	rs1800861	GT	low	1	RET - MEN2/pheochromocytoma
RET	rs1800860	AG	low	1	RET - MEN2 modifier
FOXE1	rs965513	AG	low	1	FOXE1 - thyroid cancer/function
CD28	rs1980422	CT	low	1	CD28 - Graves disease
MC4R	rs17782313	CT	low	1	MC4R - appetite/satiety
MC4R	rs571312	AC	low	1	MC4R - obesity susceptibility
PCSK1	rs6235	CG	low	1	PCSK1 - prohormone convertase
LEPR	rs1137101	AG	low	1	Leptin receptor - obesity
HMGA2	rs1042725	CT	low	1	HMGA2 - strongest height SNP
EGF	rs4444903	AG	low	1	EGF - TRPM6 regulation
NAT2	rs1495741	AG	low	1	NAT2 - novel iron GWAS locus
DHCR7	rs11234027	AG	low	1	DHCR7 - vitamin D3 production
VDR	rs7975232	AC	low	1	VDR ApaI - calcium absorption
DIO2	rs225014	CT	low	1	DIO2 Thr92Ala - T4→T3 conversion impaired
FUT6	rs602662	AG	low	1	FUT6 - vitamin B12 levels GWAS
MT-ND6	rs3928306	G	low	0	NADH dehydrogenase
MT-CYB	rs2857284	T	low	0	Electron transport
MT-RNR1	rs267606617	A	low	0	12S rRNA - ototoxicity
PPARGC1A	rs8192678	TT	low	0	Gly482Ser - metabolic efficiency
SOD2	rs1053517	AG	low	0	Ala16Val - mitochondrial antioxidant
SOD2	rs4880	AG	low	0	MnSOD - ROS protection
PPARD	rs2016520	TT	low	0	PPAR delta - metabolic switch
CPT1A	rs272893	CT	low	0	Rate-limiting for fat oxidation
FOXO3	rs2802292	TT	low	0	Stress resistance, autophagy
TOMM40	rs2075650	AA	low	0	Translocase of outer membrane
NR3C1	rs6190	CC	low	0	Glucocorticoid receptor N363S sensitivity
STAR	rs6850	--	low	0	StAR protein - steroidogenesis
GH1	rs2665802	AA	low	0	Growth hormone - GH deficiency
CASR	rs1801725	GG	low	0	Calcium-sensing receptor - FHH/hyperparathyroid
CASR	rs1042636	AA	low	0	CASR - calcium sensing variant
TSHR	rs179247	GG	low	0	TSHR - Graves susceptibility
PTPN22	rs2476601	GG	low	0	PTPN22 - autoimmune thyroid
SDHD		AA	low	0	SDHD - paraganglioma type 1
TSHR		TT	low	0	TSH receptor - Graves disease
FECH	rs2272783	AA	low	0	FECH - erythropoietic protoporphyria
ALAD	rs1800435	CC	low	0	ALAD - ALA dehydratase porphyria
PAH	rs5030855	CC	low	0	PAH - phenylketonuria
CBS	rs121964962	CC	low	0	CBS - homocystinuria
SLC2A9	rs12498742	AA	low	0	SLC2A9 GLUT9 - uric acid
ABCG2	rs2231142	GG	low	0	ABCG2 Q141K - urate efflux
SLC17A1	rs1183201	TT	low	0	SLC17A1 - urate transport
ADA	rs73598374	CC	low	0	ADA - adenosine deaminase
HFE	rs1800730	AA	low	0	HFE S65C - hemochromatosis modifier
FTO	rs9939609	TT	low	0	FTO - m6A RNA demethylase/obesity
JAK2	rs77375493	GG	low	0	JAK2 V617F - CHIP/myeloproliferative
SLC22A12		TT	low	0	URAT1 - urate reabsorption
TFR2		AA	low	0	TFR2 - hemochromatosis type 3
DNMT3A		GG	low	0	DNMT3A - CHIP/cardiovascular
DNMT3B		TT	low	0	DNMT3B - cancer/methylation
EZH2		TT	low	0	EZH2 - histone methyltransferase
FTO	rs9939609	TT	low	0	FTO - strongest BMI GWAS signal
FTO	rs1421085	TT	low	0	FTO - fat mass regulation
LYPLAL1	rs2605100	GG	low	0	LYPLAL1 - fat distribution
ADAMTS9	rs6795735	TT	low	0	ADAMTS9 - WHR
GDF5	rs143384	GG	low	0	GDF5 - height/osteoarthritis
ZBTB38	rs6763931	AG	low	0	ZBTB38 - height GWAS
KCNQ1	rs2237892	CC	low	0	KCNQ1 - Long QT/potassium
CASR	rs1801725	GG	low	0	Calcium-sensing receptor
TRPM6	rs2274924	CT	low	0	TRPM6 - magnesium channel
GC	rs4588	GG	low	0	Vitamin D binding protein
GC	rs7041	CC	low	0	GC - vitamin D transport
GC	rs2282679	TT	low	0	GC - vitamin D levels GWAS
CYP27B1	rs4646536	GG	low	0	1-alpha-hydroxylase - calcitriol
HFE	rs1800562	GG	low	0	HFE C282Y - hemochromatosis
HFE	rs1799945	CC	low	0	HFE H63D - iron overload
TF	rs3811647	GG	low	0	Transferrin - serum iron levels
SLC39A8	rs13107325	CC	low	0	ZIP8 - zinc/manganese transport
GPX1	rs1050450	AG	low	0	GPX1 - glutathione peroxidase
SELENOP	rs7579	CT	low	0	Selenoprotein P - selenium transport
TMEM18		CC	low	0	TMEM18 - early-onset obesity
GRB14		TT	low	0	GRB14 - waist-hip ratio
KCNJ11		TT	low	0	KCNJ11 - potassium/diabetes
TMPRSS6		GG	low	0	TMPRSS6 V736A - iron/hepcidin
SLC30A8		CC	low	0	ZnT8 - zinc/T2D beta-cell
GBA1	rs421016	--	low	0	GBA1 L444P - Gaucher type 2/3
CPT2	rs121434282	GG	low	0	CPT2 - CPT II deficiency
ASL	rs104894396	CC	low	0	ASL - argininosuccinic aciduria
CYP2R1	rs1562902	CC	low	0	CYP2R1 - vitamin D metabolism
VDR	rs2228570	AG	low	0	VDR FokI - transcriptional activity
VDR	rs1544410	CT	low	0	VDR BsmI - bone mineral density
VDR	rs731236	AA	low	0	VDR TaqI - vitamin D activity
DIO1	rs11206244	CC	low	0	DIO1 - selenoprotein deiodinase (T4→T3 conversion)
SLC25A4	rs121434277	GG	low	0	SLC25A4/ANT1 - adenine nucleotide translocase
TFAM	rs2020917	CC	low	0	TFAM - mitochondrial transcription factor A
PGC1A	rs7170989	CT	low	0	PGC-1alpha - mitochondrial biogenesis master regulator
PPARGC1A	rs8192678	TT	low	0	PPARGC1A Gly482Ser - mitochondrial function/T2D
UCP3	rs1800849	AA	low	0	UCP3 - uncoupling protein 3 (fat oxidation)
NBPF3	rs4654748	CC	low	0	NBPF3 - B6 levels
CYP27A1		TT	low	0	CYP27A1 - alternative 25-hydroxylase

Blood & Clotting 80 24 risk

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Gene	rsID	Genotype	Severity	Risk	Description
F11	rs4253399	TT	moderate	2	F11 - intrinsic pathway
GP1BA	rs2243093	TT	moderate	2	GPIb-alpha - von Willebrand binding
GP1BA	rs6065	CC	moderate	2	GPIb Kozak - platelet reactivity
GP6	rs1613662	AA	moderate	2	GPVI - collagen-induced aggregation
VWF	rs1063856	CC	moderate	2	VWF Thr789Ala - VWF levels
THBD	rs3176123	TT	moderate	2	Thrombomodulin - anticoagulant pathway
EDN1	rs5370	TT	moderate	2	Endothelin-1 - vasoconstriction
GP1BA	rs6065	CC	moderate	2	GP1BA - VWF binding
GP6	rs1613662	AA	moderate	2	GP6 - collagen-induced aggregation
FGB	rs1800787	CC	moderate	2	FGB -455G/A - fibrinogen levels
VWF	rs216321	CC	moderate	2	VWF - von Willebrand levels
VWF	rs1063856	CC	moderate	2	VWF - VWD modifier
CHEK2	rs17879961	AA	moderate	2	CHEK2 - blood cancer/hemolysis
F7	rs6046	AG	low	1	R353Q - reduced F7, lower MI risk
F8	rs1800291	G	low	1	F8 variant - hemophilia A related
ITGA2	rs1126643	CT	low	1	GPIa 807C>T - collagen adhesion
PROC	rs1799809	AG	low	1	PROC promoter
P2RY12	rs4524	CT	low	1	P2Y12 - thrombosis
PIK3CG	rs342293	CG	low	1	PIK3CG - platelet count
F11	rs2227589	CT	low	1	Factor XI - VTE risk
ABO	rs7853989	CG	low	1	ABO blood type - VTE risk
ABO	rs505922	CT	low	1	ABO - non-O blood type VTE
G6PD	rs1050829	T	low	1	G6PD - favism/hemolysis
HAMP	rs2227564	CT	low	1	Hepcidin - iron regulation anemia
F5	rs6025	CC	low	0	Factor V Leiden - 3-8x clot risk (80x if homozygous)
F5	rs1800595	TT	low	0	F5 R2 haplotype - mild clot risk
FGB	rs1800790	GG	low	0	-455G>A - elevated fibrinogen, CVD risk
FGB	rs1800787	CC	low	0	Fibrinogen beta chain
F7	rs561241	--	low	0	Factor VII levels
F11	rs2289252	CC	low	0	Factor XI levels - clot risk
F13A1	rs5982	GG	low	0	F13A1 variant - clot stability
F13B	rs5987	CC	low	0	F13B - clot cross-linking
PAI-1	rs2227631	AA	low	0	PAI-1 4G/5G - impaired clot breakdown
ITGB3	rs5918	TT	low	0	GPIIIa PlA2 - increased platelet aggregation
CYP1A2	rs762551	AA	low	0	Caffeine-platelet interaction
VWF	rs1800378	TT	low	0	VWF - vascular hemostasis
PROC	rs1799808	CC	low	0	Protein C - natural anticoagulant
NOS3	rs2070744	TT	low	0	eNOS promoter - NO production
MTHFR	rs1801133	AG	low	0	C677T - elevated homocysteine if low folate
ABO	rs8176719	--	low	0	O blood type (deletion) - lower VWF/clot risk
F11		TT	low	0	F11 - intrinsic pathway
GP1BA		TT	low	0	GPIb-alpha - von Willebrand binding
GP1BA		CC	low	0	GPIb Kozak - platelet reactivity
GP6		AA	low	0	GPVI - collagen-induced aggregation
VWF		CC	low	0	VWF Thr789Ala - VWF levels
THBD		TT	low	0	Thrombomodulin - anticoagulant pathway
EDN1		TT	low	0	Endothelin-1 - vasoconstriction
TMPRSS6	rs855791	GG	low	0	TMPRSS6 - iron deficiency anemia
TMPRSS6	rs4820268	AA	low	0	TMPRSS6 - hepcidin regulation
HFE	rs1800562	GG	low	0	HFE C282Y - hemochromatosis
HFE	rs1799945	CC	low	0	HFE H63D - iron loading
TFR2	rs7385804	AA	low	0	TFR2 - iron metabolism
HBB	rs33930165	CC	low	0	HBB - beta thalassemia carrier
HBA1	rs63751128	TT	low	0	HBA1 - alpha thalassemia
ITGB3	rs5918	TT	low	0	GPIIIa PlA1/A2 - platelet reactivity
F5	rs6025	CC	low	0	Factor V Leiden - clotting
F9	rs6048	A	low	0	Factor IX - hemophilia B carrier
FGB	rs1800790	GG	low	0	Fibrinogen beta - clotting
F11	rs2289252	CC	low	0	F11 - intrinsic pathway
F8	rs710446	TT	low	0	Factor VIII levels
VWF	rs1800378	TT	low	0	VWF - bleeding risk
MTHFR	rs1801133	AG	low	0	MTHFR C677T - homocysteine/clotting
MTHFR	rs1801131	TT	low	0	MTHFR A1298C - folate/clotting
ACKR1	rs2814778	TT	low	0	Duffy-null - benign ethnic neutropenia
NOS3	rs3918226	CC	low	0	eNOS - leukocyte function
JAK2	rs77375493	GG	low	0	JAK2 V617F - MPN screening
ITPA	rs1127354	CC	low	0	ITPA - ribavirin anemia
ITPA	rs7270101	AA	low	0	ITPA - drug-induced anemia
G6PD	rs1050828	C	low	0	G6PD African variant
IL6	rs1800795	GG	low	0	IL-6 - hematopoiesis
THPO	rs1541252	CC	low	0	Thrombopoietin - platelet production
EPO	rs1617640	AA	low	0	EPO promoter - RBC production
EPOR	rs551238	TT	low	0	EPO receptor - erythropoiesis
ABO	rs8176719	--	low	0	ABO - antiphospholipid risk
GP1BA		CC	low	0	GP1BA - VWF binding
GP6		AA	low	0	GP6 - collagen-induced aggregation
FGB		CC	low	0	FGB -455G/A - fibrinogen levels
VWF		CC	low	0	VWF - von Willebrand levels
VWF		CC	low	0	VWF - VWD modifier
CHEK2		AA	low	0	CHEK2 - blood cancer/hemolysis

Brain & Nerves 57 22 risk

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Gene	rsID	Genotype	Severity	Risk	Description
CLU	rs11136000	CC	moderate	2	Clusterin - late-onset AD
CLU	rs9331888	CC	moderate	2	Clusterin haplotype
SCARB2	rs6812193	TT	moderate	2	GBA receptor - PD
STK39	rs4538475	AA	moderate	2	STK39 - PD risk
CYP27B1	rs2248359	CC	moderate	2	Vitamin D metabolism - MS
TERT	rs2736100	CC	moderate	2	TERT - diabetic neuropathy
SLC30A8	rs13266634	CC	moderate	2	ZnT8 - diabetic neuropathy
PTPRD	rs1975197	AA	moderate	2	PTPRD - RLS/PLMD
LINGO1	rs9652490	AA	moderate	2	LINGO1 - essential tremor
TRPM8	rs10166942	TT	moderate	2	TRPM8 cold receptor - migraine
UNC13A	rs12608932	CC	moderate	2	UNC13A - ALS susceptibility
CD33	rs3865444	AC	low	1	CD33 - microglial activation
MS4A6A	rs610932	GT	low	1	MS4A6A - AD risk
SNCA	rs356219	AG	low	1	Alpha-synuclein - PD risk
SNCA	rs11931074	GT	low	1	SNCA - synuclein aggregation
SNCA	rs356220	CT	low	1	SNCA Rep1 proxy - PD
RIT2	rs12456492	AG	low	1	RIT2 - PD susceptibility
IL7R	rs6897932	CT	low	1	IL-7 receptor - MS susceptibility
HLA-A	rs2283792	GT	low	1	HLA-A*02:01 - MS protective
KCNQ2	rs10499563	CT	low	1	KCNQ2 - benign epilepsy
BTBD9	rs3923809	AG	low	1	BTBD9 - RLS major locus
PRDM16	rs2651899	CT	low	1	PRDM16 - migraine susceptibility
APOE	rs429358	TT	low	0	APOE ε4 - major Alzheimer's risk
APOE	rs7412	CC	low	0	APOE ε2 - Alzheimer's protective
CR1	rs6656401	GG	low	0	Complement receptor 1 - AD risk
ABCA7	rs3764650	TT	low	0	ABCA7 - amyloid processing
PICALM	rs3851179	CC	low	0	PICALM - endocytosis, AD
BIN1	rs744373	AA	low	0	BIN1 - tau pathology
CD2AP	rs9349407	GG	low	0	CD2AP - AD susceptibility
TOMM40	rs2075650	AA	low	0	TOMM40 - cognitive aging
BST1	rs1724425	TT	low	0	BST1 - PD risk
GBA	rs34311866	CC	low	0	Glucocerebrosidase - PD/Gaucher
HLA-DRB1	rs3135388	GG	low	0	HLA-DRB1*15:01 - major MS risk
IL2RA	rs12722489	CC	low	0	IL-2 receptor alpha - MS
IL2RA	rs2104286	TT	low	0	IL2RA - T cell regulation
CD86	rs9282641	GG	low	0	CD86 - immune activation
TNFRSF1A	rs1800693	TT	low	0	TNF receptor - MS risk
SCN1A	rs28937318	CC	low	0	SCN1A - Dravet syndrome
BRD2	rs11890028	TT	low	0	BRD2 - JME susceptibility
IL28B	rs12979860	--	low	0	Interferon - HCV neuropathy
MEIS1	rs2300478	TT	low	0	MEIS1 - RLS susceptibility
LINGO1	rs11856808	CC	low	0	LINGO1 - tremor susceptibility
SLC1A2	rs3794087	GG	low	0	Glutamate transporter - tremor
C9orf72	rs3849942	CC	low	0	C9orf72 region - ALS/FTD
BDNF	rs6265	CC	low	0	BDNF Val66Met - reduced neuroplasticity
FOXO3	rs2802292	TT	low	0	FOXO3 - neuroprotection, longevity
CLU		CC	low	0	Clusterin - late-onset AD
CLU		CC	low	0	Clusterin haplotype
SCARB2		TT	low	0	GBA receptor - PD
STK39		AA	low	0	STK39 - PD risk
CYP27B1		CC	low	0	Vitamin D metabolism - MS
TERT		CC	low	0	TERT - diabetic neuropathy
SLC30A8		CC	low	0	ZnT8 - diabetic neuropathy
PTPRD		AA	low	0	PTPRD - RLS/PLMD
LINGO1		AA	low	0	LINGO1 - essential tremor
TRPM8		TT	low	0	TRPM8 cold receptor - migraine
UNC13A		CC	low	0	UNC13A - ALS susceptibility

Kidneys 55 17 risk

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Gene	rsID	Genotype	Severity	Risk	Description
UMOD	rs12917707	GG	moderate	2	Uromodulin variant - reduced eGFR
CST3	rs6495446	CC	moderate	2	Affects cystatin C levels (kidney function marker)
SLC2A9	rs1014290	AA	moderate	2	Uric acid transporter - stone risk
VDR	rs11568820	CC	moderate	2	Vitamin D receptor - kidney mineral handling
TGFB1	rs1800471	CC	moderate	2	TGF-beta - fibrosis/scarring in kidney
CRP	rs1205	CC	moderate	2	C-reactive protein - inflammation marker
UMOD	rs12917707	GG	moderate	2	Uromodulin - CKD major locus
WDR72	rs10109414	CC	moderate	2	WDR72 - eGFR
SLC12A3	rs11643718	GG	moderate	2	Thiazide-sensitive cotransporter
SLC2A9	rs12654812	AA	moderate	2	Urate transporter - uric acid stones
SLC2A9	rs1014290	AA	moderate	2	SLC2A9 - kidney stones
PLA2R1	rs4664308	AA	moderate	2	PLA2R1 - membranous nephropathy
GCKR	rs1260326	CT	low	1	Glucokinase regulator - metabolic kidney effects
HLA-DQ	rs2856717	AG	low	1	IgA nephropathy susceptibility
VEGFA	rs2010963	CG	low	1	VEGF - vascular/kidney protection
HLA-DQ	rs2856717	AG	low	1	HLA-DQ - IgA nephropathy
IRF5	rs10954213	AG	low	1	IRF5 - lupus nephritis
UMOD	rs4293393	AA	low	0	Uromodulin - major CKD risk gene
ABCG2	rs2231142	GG	low	0	Urate efflux - high uric acid
CYP3A4	rs2740574	TT	low	0	Drug metabolism affecting kidney
CYP3A5	rs776746	CT	low	0	CYP3A5 expresser - faster tacrolimus clearance
EPO	rs1617640	AA	low	0	Erythropoietin - diabetic kidney disease
HLA-DQ	rs9275596	TT	low	0	IgA nephropathy risk
AGTR1	rs5186	AA	low	0	Angiotensin receptor - BP effect on kidney
AGT	rs699	AG	low	0	Angiotensinogen - blood pressure/kidney
UMOD	rs4293393	AA	low	0	UMOD - CKD/hypertension
SHROOM3	rs2467853	TT	low	0	SHROOM3 - eGFR decline
CST3	rs911119	CT	low	0	CST3 - renal function
NAT8	rs10206899	CT	low	0	NAT8 - CKD progression
SHROOM3	rs17319721	GG	low	0	SHROOM3 - CKD susceptibility
PIP5K1B	rs4744712	CC	low	0	PIP5K1B - kidney function
PRKAG2	rs7805747	GG	low	0	PRKAG2 - CKD
EPO	rs12523822	CT	low	0	Erythropoietin - diabetic nephropathy
VEGFA	rs13293564	GG	low	0	VEGF - diabetic nephropathy
CLDN14	rs6088813	CC	low	0	Claudin-14 - calcium stones
CASR	rs4726443	CC	low	0	Calcium sensing receptor - stones
GALC	rs2412971	AG	low	0	GALC - IgA nephropathy risk
ITGAM	rs11150612	GG	low	0	ITGAM - IgA nephropathy
APOL1	rs72474224	CC	low	0	APOL1 G1 - FSGS (African ancestry)
MYH9	rs1871534	GG	low	0	MYH9 - FSGS susceptibility
AGT	rs699	AG	low	0	AGT M235T - hypertensive kidney damage
AGT	rs4762	GG	low	0	AGT T174M - nephropathy
AGTR1	rs5186	AA	low	0	AT1 receptor - renal damage
SCN9A	rs1805124	TT	low	0	Nav1.7 - renal sodium
ITGAM	rs1143679	GG	low	0	CD11b - lupus nephritis major
FAM167A	rs10488631	TT	low	0	BLK locus - lupus nephritis
STAT4	rs7574865	GG	low	0	STAT4 - lupus nephritis
VHL	rs12105918	TT	low	0	VHL region - RCC risk
SCARB1	rs7105934	AG	low	0	SCARB1 - RCC susceptibility
UMOD		GG	low	0	Uromodulin - CKD major locus
WDR72		CC	low	0	WDR72 - eGFR
SLC12A3		GG	low	0	Thiazide-sensitive cotransporter
SLC2A9		AA	low	0	Urate transporter - uric acid stones
SLC2A9		AA	low	0	SLC2A9 - kidney stones
PLA2R1		AA	low	0	PLA2R1 - membranous nephropathy

Mental Health 55 19 risk

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Gene	rsID	Genotype	Severity	Risk	Description
LHPP	rs1545843	AA	moderate	2	LHPP - major depression
CRHR1	rs2267735	CC	moderate	2	CRHR1 - PTSD risk
ANK3	rs9804190	CC	moderate	2	ANK3 - neuronal excitability
SYNE1	rs2727943	TT	moderate	2	SYNE1 - bipolar disorder
NRGN	rs12807809	TT	moderate	2	Neurogranin - schizophrenia
VRK2	rs2312147	CC	moderate	2	VRK2 - schizophrenia
TRIM26	rs4129585	CC	moderate	2	MHC region - schizophrenia
FKBP5	rs3800373	AA	moderate	2	FKBP5 - HPA axis dysregulation
SLC1A1	rs301443	CC	moderate	2	EAAC1 - OCD glutamate
CDH9/CDH10	rs4307059	CC	moderate	2	Cadherin - autism
MET	rs1858830	CC	moderate	2	MET receptor - autism
HTR1A	rs6295	CG	low	1	5-HT1A - depression, anxiety
COMT	rs4680	AG	low	1	COMT - ADHD, working memory
PCLO	rs2522833	AC	low	1	Piccolo - major depression
RGS2	rs878886	CG	low	1	RGS2 - anxiety susceptibility
ADRA2A	rs1800544	CG	low	1	Alpha-2A adrenergic - ADHD
DRD4	rs1800955	CT	low	1	DRD4 - ADHD, novelty seeking
OXTR	rs53576	AG	low	1	Oxytocin receptor - empathy, social
OXTR	rs1042778	GT	low	1	OXTR - social behavior
HTR2A	rs6313	GG	low	0	5-HT2A receptor - depression/SSRI response
HTR2A	rs6311	CC	low	0	HTR2A promoter - depression
HTR2A	rs7997012	AA	low	0	HTR2A - antidepressant response
SLC6A4	rs25531	--	low	0	5-HTTLPR proxy - stress depression
BDNF	rs6265	CC	low	0	BDNF Val66Met - depression risk
CACNA1C	rs1006737	GG	low	0	Calcium channel - bipolar
MTHFR	rs1801133	AG	low	0	MTHFR - folate/depression link
TPH2	rs4570625	GG	low	0	TPH2 - anxiety, panic
NPY	rs322931	GG	low	0	NPY - stress resilience
ANK3	rs10994336	CC	low	0	ANK3 - bipolar disorder
ODZ4	rs7570682	GG	low	0	ODZ4/TENM4 - bipolar
TCF4	rs6904071	GG	low	0	TCF4 - schizophrenia risk
SLC39A8	rs13107325	CC	low	0	Zinc transporter - schizophrenia
ZNF804A	rs1344706	AA	low	0	ZNF804A - psychosis risk
FKBP5	rs1360780	CC	low	0	FKBP5 - stress response
FKBP5	rs9470080	CC	low	0	FKBP5 - childhood trauma response
DRD2	rs12364283	AA	low	0	DRD2 - PTSD susceptibility
BTBD3	rs6131295	AA	low	0	BTBD3 - OCD susceptibility
SLC1A1	rs3780412	CC	low	0	SLC1A1 - OCD risk
SLC6A3	rs27072	CC	low	0	DAT1 - ADHD
CLOCK	rs1801260	AA	low	0	CLOCK - ADHD, circadian
CNTNAP2	rs7794745	AA	low	0	CNTNAP2 - autism, language
CNTNAP2	rs2710102	AG	low	0	CNTNAP2 - autism susceptibility
NR3C2	rs5522	TT	low	0	Mineralocorticoid receptor - stress
OXTR	rs2254298	GG	low	0	OXTR - social anxiety
LHPP		AA	low	0	LHPP - major depression
CRHR1		CC	low	0	CRHR1 - PTSD risk
ANK3		CC	low	0	ANK3 - neuronal excitability
SYNE1		TT	low	0	SYNE1 - bipolar disorder
NRGN		TT	low	0	Neurogranin - schizophrenia
VRK2		CC	low	0	VRK2 - schizophrenia
TRIM26		CC	low	0	MHC region - schizophrenia
FKBP5		AA	low	0	FKBP5 - HPA axis dysregulation
SLC1A1		CC	low	0	EAAC1 - OCD glutamate
CDH9/CDH10		CC	low	0	Cadherin - autism
MET		CC	low	0	MET receptor - autism

Cancer Risk 53 18 risk

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Gene	rsID	Genotype	Severity	Risk	Description
SCARB1	rs11057830	GG	moderate	2	SCARB1 - RCC GWAS locus
BNC2	rs3814113	CC	moderate	2	9p22 - serous ovarian cancer GWAS
SLC45A2	rs16891982	CC	moderate	2	SLC45A2 - pigmentation/melanoma
ADH1B	rs1229984	CC	moderate	2	ADH1B - alcohol/esophageal cancer
DMRT1	rs755383	TT	moderate	2	9p24.3 - testicular cancer
BAK1	rs210138	AA	moderate	2	6p21.31 - testicular cancer
GSDMB	rs2290400	TT	moderate	2	17q12 - cervical cancer risk
NAT2	rs1208	AG	low	1	NAT2 - bladder cancer/carcinogen metabolism
MYC	rs9642880	GT	low	1	8q24 MYC - bladder cancer susceptibility
CLPTM1L	rs401681	CT	low	1	CLPTM1L-TERT - shared cancer locus
SLC14A1	rs10775480	CT	low	1	Urea transporter - bladder cancer
ABO	rs505922	CT	low	1	ABO blood group - pancreatic cancer
CDKN2A	rs3731239	AG	low	1	CDKN2A - melanoma/pancreatic cancer
CDKN2A/B	rs4977756	AG	low	1	9p21.3 - glioma susceptibility
PTCH1	rs227731	GT	low	1	PTCH1 - basal cell carcinoma
FOXE1	rs965513	AG	low	1	FOXE1 - strongest thyroid cancer GWAS
PLCE1	rs2274223	AG	low	1	10q23 - esophageal/gastric cancer
ARID5B	rs10821936	CT	low	1	ARID5B - childhood ALL susceptibility
NAT2	rs1799930	GG	low	0	NAT2 slow acetylator - aromatic amine metabolism
TP63	rs710521	CT	low	0	TP63 - bladder cancer risk locus
APOBEC3A	rs1014971	CC	low	0	APOBEC mutagenesis - bladder cancer
ITPR2	rs718314	AA	low	0	ITPR2 - RCC GWAS locus
BRIP1	rs4986764	AG	low	0	BRIP1 - Fanconi/ovarian cancer
NR5A2	rs3790844	AG	low	0	1q32.1 - pancreatic ductal adenocarcinoma
RTEL1	rs6010620	GG	low	0	20q13.33 - glioma/telomere maintenance
PHLDB1	rs498872	GG	low	0	11q23.3 - glioma risk
TP53	rs78378222	TT	low	0	TP53 3'UTR - glioma GWAS
MC1R	rs1805007	CC	low	0	MC1R R151C - red hair/melanoma
MC1R	rs1805008	CC	low	0	MC1R R160W - melanoma susceptibility
TYR	rs1126809	--	low	0	Tyrosinase - melanoma susceptibility
IRF4	rs12203592	CC	low	0	IRF4 - pigmentation/melanoma risk
HLA-C	rs10484554	CT	low	0	HLA-C*06:02 - psoriasis/melanoma
NKX2-1	rs944289	CC	low	0	14q13.3 - papillary thyroid cancer
DIRC3	rs966423	CC	low	0	2q35 - thyroid cancer GWAS
MUC1	rs4072037	TT	low	0	MUC1 - gastric cancer susceptibility
ALDH2	rs671	GG	low	0	ALDH2 - alcohol/esophageal cancer
PSCA	rs2294008	CC	low	0	PSCA - gastric cancer GWAS
KITLG	rs995030	AA	low	0	KITLG - strongest testicular cancer signal
KITLG	rs1508595	AA	low	0	KITLG - testicular germ cell tumors
TERT	rs4635969	GG	low	0	5p15.33 - testicular cancer
MICA	rs2596542	CT	low	0	MICA - cervical/HBV-HCC cancer
IKZF1	rs4132601	TT	low	0	IKZF1 - ALL susceptibility
CEBPE	rs2239633	GG	low	0	CEBPE - ALL risk
PIP4K2A	rs7088318	AC	low	0	PIP4K2A - ALL susceptibility
HLA	rs2647012	CT	low	0	6p21.3 - Hodgkin lymphoma
LPP	rs1432295	AA	low	0	LPP - follicular lymphoma
SCARB1		GG	low	0	SCARB1 - RCC GWAS locus
BNC2		CC	low	0	9p22 - serous ovarian cancer GWAS
SLC45A2		CC	low	0	SLC45A2 - pigmentation/melanoma
ADH1B		CC	low	0	ADH1B - alcohol/esophageal cancer
DMRT1		TT	low	0	9p24.3 - testicular cancer
BAK1		AA	low	0	6p21.31 - testicular cancer
GSDMB		TT	low	0	17q12 - cervical cancer risk

Digestive 50 20 risk

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Gene	rsID	Genotype	Severity	Risk	Description
IL23R	rs7517847	TT	moderate	2	IL-23R - IBD susceptibility
FCGR2A	rs1801274	AA	moderate	2	Fc receptor - ulcerative colitis
IL23R	rs11465804	TT	moderate	2	IL-23R - Crohn's risk
IRGM	rs6596075	CC	moderate	2	IRGM - autophagy, Crohn's
HLA-DQ8	rs7454108	TT	moderate	2	HLA-DQ8 - celiac disease
IL18RAP	rs13119723	AA	moderate	2	IL-18 receptor - celiac
NPSR1	rs324981	TT	moderate	2	NPSR1 - IBS/anxiety link
IL1B	rs16944	AA	moderate	2	IL-1B - gastric cancer/ulcer
SPINK1	rs7190458	GG	moderate	2	SPINK1 - chronic pancreatitis
LCT	rs4988235	GG	moderate	2	Lactase persistence - lactose intolerance
STAT3	rs744166	AG	low	1	STAT3 - IBD susceptibility
TNFSF15	rs4263839	AG	low	1	TNFSF15 - IBS susceptibility
TNFSF15	rs6478108	CT	low	1	TL1A - IBS/IBD
TNFSF15	rs6478109	AG	low	1	TNFSF15 haplotype - IBS
PRSS1	rs10273639	CT	low	1	PRSS1 - pancreatitis risk
ABCG8	rs4245791	CT	low	1	ABCG8 - cholesterol gallstones
ABCG5	rs6544713	CT	low	1	ABCG5 - sitosterolemia/gallstones
FUT2	rs601338	AG	low	1	Non-secretor - gut microbiome composition
FUT2	rs602662	AG	low	1	FUT2 - Bifidobacteria levels
SMAD7	rs4939827	CT	low	1	SMAD7 - colorectal cancer
ATG16L1	rs2241880	AA	low	0	ATG16L1 T300A - Crohn's disease
ATG16L1	rs10210302	CC	low	0	Autophagy - IBD risk
IL23R	rs11209026	GG	low	0	IL-23 receptor - IBD protective if G
IL23R	rs1004819	AA	low	0	IL-23R - Crohn's/UC risk
NOD2	rs2066847	DD	low	0	NOD2 frameshift - major Crohn's risk
NOD2	rs2066844	CC	low	0	NOD2 R702W - Crohn's susceptibility
NOD2	rs2066845	GG	low	0	NOD2 G908R - Crohn's risk
HLA-DRA	rs3135388	GG	low	0	HLA-DRA - IBD association
HLA-DQ2.5	rs2187668	CC	low	0	HLA-DQ2.5 - major celiac risk
IL2/IL21	rs6822844	GG	low	0	IL-2/IL-21 - celiac susceptibility
IL18RAP	rs917997	CC	low	0	IL-18RAP - celiac risk
CNTNAP2	rs2710102	AG	low	0	CNTNAP2 - IBS/brain-gut
TLR4	rs4986790	AA	low	0	TLR4 - H. pylori susceptibility
TLR4	rs4986791	CC	low	0	TLR4 - gastric inflammation
IL1B	rs1143634	GG	low	0	IL-1B - H. pylori outcomes
CFTR	rs11988997	CC	low	0	CFTR - pancreatic function
ABCG8	rs11887534	GG	low	0	ABCG8 D19H - gallstone risk
MCM6/LCT	rs182549	CC	low	0	Lactase - microbiome (dairy impact)
8q24	rs6983267	TT	low	0	8q24 - colorectal cancer risk
RHPN2	rs10411210	CC	low	0	RHPN2 - colorectal susceptibility
IL23R		TT	low	0	IL-23R - IBD susceptibility
FCGR2A		AA	low	0	Fc receptor - ulcerative colitis
IL23R		TT	low	0	IL-23R - Crohn's risk
IRGM		CC	low	0	IRGM - autophagy, Crohn's
HLA-DQ8		TT	low	0	HLA-DQ8 - celiac disease
IL18RAP		AA	low	0	IL-18 receptor - celiac
NPSR1		TT	low	0	NPSR1 - IBS/anxiety link
IL1B		AA	low	0	IL-1B - gastric cancer/ulcer
SPINK1		GG	low	0	SPINK1 - chronic pancreatitis
LCT		GG	low	0	Lactase persistence - lactose intolerance

Lungs 45 16 risk

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Gene	rsID	Genotype	Severity	Risk	Description
SERPINA1	rs17580	TT	moderate	2	AAT S allele - lung damage
HHIP	rs13180	CC	moderate	2	Hedgehog interacting - COPD
ORMDL3	rs7216389	TT	moderate	2	ORMDL3 - asthma susceptibility
GSDMB	rs2305480	GG	moderate	2	Gasdermin B - asthma
TERT	rs2736100	CC	moderate	2	TERT - lung cancer risk
TERT	rs2853677	GG	moderate	2	TERT - multiple cancers
VTI1A	rs7086803	GG	moderate	2	VTI1A - lung adenocarcinoma
ANXA11	rs1980493	TT	moderate	2	Annexin A11 - sarcoidosis
LPAR1	rs1409986	GG	moderate	2	LPAR1 - OSA susceptibility
INTS12	rs11727189	GG	moderate	2	INTS12 - lung function
GSTCD	rs10516526	AA	moderate	2	GST - lung function, oxidative stress
SPINK5	rs324011	CT	low	1	Kazal protease - atopic asthma
DSP	rs2076295	GT	low	1	Desmoplakin - IPF
DPP9	rs12610495	AG	low	1	DPP9 - IPF susceptibility
FAM13A	rs2034650	AG	low	1	FAM13A - IPF
TNS1	rs2571445	AG	low	1	Tensin 1 - FEV1 decline
SERPINA1	rs28929474	CC	low	0	Alpha-1 antitrypsin Z allele - COPD
FAM13A	rs7671167	TT	low	0	FAM13A - COPD susceptibility
CHRNA3/5	rs8034191	TT	low	0	15q25 - smoking/COPD link
CHRNA3	rs1051730	GG	low	0	15q25 - lung cancer
ORMDL3	rs8076131	AA	low	0	17q21 - childhood asthma
PDE4D	rs2786098	GG	low	0	PDE4D - asthma/COPD
IL13	rs1800925	CC	low	0	IL-13 promoter - asthma
IL13	rs20541	GG	low	0	IL-13 R130Q - asthma/atopy
IL13	rs1295686	CC	low	0	IL-13 - allergic asthma
IL4	rs2243250	CC	low	0	IL-4 promoter - asthma
CHRNA5	rs16969968	GG	low	0	CHRNA5 D398N - lung cancer
CLPTM1L	rs2352028	CC	low	0	CLPTM1L/TERT - lung cancer
HLA-DRA	rs3129882	GG	low	0	HLA-DRA - sarcoidosis
AGTR1	rs5186	AA	low	0	AT1 receptor - pulmonary vascular
SIRT1	rs10519203	AA	low	0	Sirtuin 1 - vascular function
CFTR	rs78655421	GG	low	0	CFTR - CF susceptibility
TIRAP	rs8177374	CC	low	0	TIRAP - pneumonia susceptibility
TLR4	rs4986790	AA	low	0	TLR4 - RSV severity
SERPINA1		TT	low	0	AAT S allele - lung damage
HHIP		CC	low	0	Hedgehog interacting - COPD
ORMDL3		TT	low	0	ORMDL3 - asthma susceptibility
GSDMB		GG	low	0	Gasdermin B - asthma
TERT		CC	low	0	TERT - lung cancer risk
TERT		GG	low	0	TERT - multiple cancers
VTI1A		GG	low	0	VTI1A - lung adenocarcinoma
ANXA11		TT	low	0	Annexin A11 - sarcoidosis
LPAR1		GG	low	0	LPAR1 - OSA susceptibility
INTS12		GG	low	0	INTS12 - lung function
GSTCD		AA	low	0	GST - lung function, oxidative stress

Liver 42 16 risk

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Gene	rsID	Genotype	Severity	Risk	Description
MBOAT7	rs641738	TT	moderate	2	MBOAT7 - NAFLD susceptibility
LYPLAL1	rs12137855	CC	moderate	2	Lysophospholipase - fat distribution
SERPINA1	rs17580	TT	moderate	2	AAT S allele - carrier status
HLA-DQ	rs9275319	AA	moderate	2	HLA-DQ - HBV clearance/HCC
HNF1A	rs7310409	GG	moderate	2	HNF1A - GGT/ALP levels
HNF4A	rs1800961	CC	moderate	2	HNF4A - liver function
GCKR	rs780094	CT	low	1	Glucokinase regulator - liver fat
GCKR	rs1260326	CT	low	1	GCKR P446L - triglycerides/liver fat
MERTK	rs4374383	AG	low	1	MERTK - hepatic fibrosis progression
UGT1A1	rs887829	CT	low	1	UGT1A1*80 - Gilbert's syndrome
UGT1A1	rs6742078	GT	low	1	UGT1A1 - bilirubin glucuronidation
ABCG8	rs4245791	CT	low	1	ABCG8 - cholesterol secretion
ADH1C	rs1693482	CT	low	1	ADH1C - alcohol to acetaldehyde
PNPLA3	rs2862954	CT	low	1	ALT levels
ATP7B	rs1801243	AC	low	1	Wilson's disease carrier
SLCO1B1	rs2306283	AG	low	1	SLCO1B1 - hepatic drug uptake
PNPLA3	rs738409	CC	low	0	PNPLA3 I148M - major NAFLD/NASH risk
NCAN	rs2228603	CC	low	0	Neurocan - fatty liver
SERPINA1	rs28929474	CC	low	0	Alpha-1 antitrypsin Z allele - liver disease
UGT1A1	rs4148323	GG	low	0	UGT1A1*6 - Gilbert's (Asian)
HFE	rs1800562	GG	low	0	HFE C282Y - hereditary hemochromatosis
HFE	rs1799945	CC	low	0	HFE H63D - iron loading
TMPRSS6	rs855791	GG	low	0	TMPRSS6 - iron deficiency risk
TMPRSS6	rs4820268	AA	low	0	Hepcidin regulation - iron status
KIF1B	rs17401966	AA	low	0	KIF1B - HCC in HBV
STAT4	rs7574865	GG	low	0	STAT4 - HBV-related HCC
PTPN22	rs2476601	GG	low	0	PTPN22 - drug-induced hepatotoxicity
IL28B	rs12979860	--	low	0	IL28B - HCV treatment response
IL28B	rs8099917	TT	low	0	IL28B - HCV clearance
ABCG8	rs11887534	GG	low	0	ABCG8 D19H - gallstones
CYP7A1	rs3808607	TT	low	0	Cholesterol 7-alpha hydroxylase
ALDH2	rs671	GG	low	0	ALDH2*2 - acetaldehyde buildup, liver damage
ADH1B	rs1229984	CC	low	0	ADH1B*2 - fast alcohol metabolism
ATP7B	rs732774	CT	low	0	ATP7B - copper metabolism
ABCG2	rs2231142	GG	low	0	BCRP - drug efflux transporter
SLCO1B1	rs4149056	TT	low	0	OATP1B1 - statin myopathy
MBOAT7		TT	low	0	MBOAT7 - NAFLD susceptibility
LYPLAL1		CC	low	0	Lysophospholipase - fat distribution
SERPINA1		TT	low	0	AAT S allele - carrier status
HLA-DQ		AA	low	0	HLA-DQ - HBV clearance/HCC
HNF1A		GG	low	0	HNF1A - GGT/ALP levels
HNF4A		CC	low	0	HNF4A - liver function

Diabetes 38 20 risk

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Gene	rsID	Genotype	Severity	Risk	Description
KCNJ11	rs5219	TT	moderate	2	KCNJ11 E23K - insulin secretion
SLC30A8	rs13266634	CC	moderate	2	ZnT8 - T2D risk
HHEX	rs1111875	CC	moderate	2	HHEX - T2D
CDKN2A/B	rs10811661	TT	moderate	2	CDKN2A/B - T2D
G6PC2	rs560887	CC	moderate	2	G6PC2 - fasting glucose
SLC30A8	rs11558471	AA	moderate	2	ZnT8 - T2D
IRS1	rs2943641	CC	moderate	2	IRS1 - T2D susceptibility
THADA	rs7578597	TT	moderate	2	THADA - T2D
KCNQ1	rs231362	GG	moderate	2	KCNQ1 - T2D
KCNQ1	rs2237892	CC	moderate	2	KCNQ1 - T2D (Asian)
TCF7L2	rs7903146	CT	low	1	TCF7L2 - major T2D risk
TCF7L2	rs12255372	GT	low	1	TCF7L2 - T2D
MTNR1B	rs10830963	CG	low	1	Melatonin receptor - glucose
MTNR1B	rs1387153	CT	low	1	MTNR1B - fasting glucose
GCKR	rs780094	CT	low	1	GCKR - glucose homeostasis
DGKB	rs2191349	GT	low	1	DGKB - fasting glucose
JAZF1	rs864745	CT	low	1	JAZF1 - T2D
NOTCH2	rs10923931	GT	low	1	NOTCH2 - T2D
CDC123	rs12779790	AG	low	1	CDC123/CAMK1D - T2D
TSPAN8	rs7961581	CT	low	1	TSPAN8/LGR5 - T2D
PPARG	rs1801282	CC	low	0	PPARG Pro12Ala - insulin
CDKAL1	rs7754840	GG	low	0	CDKAL1 - T2D
IGF2BP2	rs4402960	GG	low	0	IGF2BP2 - T2D
FTO	rs8050136	CC	low	0	FTO - obesity, T2D
FTO	rs9939609	TT	low	0	FTO - obesity
IRS1	rs1801278	CC	low	0	IRS1 - T2D
ADAMTS9	rs4607103	TT	low	0	ADAMTS9 - T2D
IGF2BP2	rs1470579	AA	low	0	IGF2BP2 - T2D
KCNJ11		TT	low	0	KCNJ11 E23K - insulin secretion
SLC30A8		CC	low	0	ZnT8 - T2D risk
HHEX		CC	low	0	HHEX - T2D
CDKN2A/B		TT	low	0	CDKN2A/B - T2D
G6PC2		CC	low	0	G6PC2 - fasting glucose
SLC30A8		AA	low	0	ZnT8 - T2D
IRS1		CC	low	0	IRS1 - T2D susceptibility
THADA		TT	low	0	THADA - T2D
KCNQ1		GG	low	0	KCNQ1 - T2D
KCNQ1		CC	low	0	KCNQ1 - T2D (Asian)

Lipid 22 12 risk

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Gene	rsID	Genotype	Severity	Risk	Description
SORT1	rs646776	TT	moderate	2	SORT1 - LDL cholesterol
SORT1	rs12740374	GG	moderate	2	SORT1 - hepatic LDL uptake
PCSK9	rs11206510	TT	moderate	2	PCSK9 - cholesterol
HNF4A	rs1800961	CC	moderate	2	HNF4A - HDL
FADS1	rs102275	TT	moderate	2	FADS1 - PUFA conversion
APOB	rs515135	CT	low	1	ApoB - LDL particles
CETP	rs3764261	AC	low	1	CETP - HDL cholesterol
LIPC	rs1532085	AG	low	1	Hepatic lipase - HDL
APOA5	rs662799	AG	low	1	APOA5 - triglycerides
APOA1	rs964184	CG	low	1	ZNF259/APOA5 - TG
GCKR	rs780094	CT	low	1	GCKR - TG/glucose
GCKR	rs1260326	CT	low	1	GCKR P446L - TG
LDLR	rs6511720	GG	low	0	LDL receptor - cholesterol
APOB	rs1367117	GG	low	0	APOB - LDL cholesterol
SORT1	rs2306692	CC	low	0	SORT1 - LDL
PCSK9	rs11591147	GG	low	0	PCSK9 - LDL, statin-like
LIPC	rs1800588	CC	low	0	LIPC - HDL levels
LPL	rs328	CC	low	0	LPL S447X - lower TG
FADS1	rs174547	TT	low	0	FADS1 - omega-3/6
FADS1	rs174546	CC	low	0	FADS1 - fatty acid desaturase
APOE	rs7412	CC	low	0	APOE e2 - lower cholesterol
APOE	rs429358	TT	low	0	APOE e4 - higher cholesterol

Unknown 20

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Gene	rsID	Genotype	Severity	Description
APOE	rs429358	TT	low	ε4 allele (C)
APOE	rs7412	CC	low	ε2 allele (T)
ALDH2	rs671	GG	low	Asian flush
ADH1B	rs1229984	CC	low	Fast alcohol metabolism
CYP1A2	rs762551	AA	low	Caffeine metabolism
ACTN3	rs1815739	CT	low	R577X
BCMO1	rs12934922	AT	low	Beta-carotene conversion
BCMO1	rs7501331	CC	low	Carotenoid conversion
COMT	rs4680	AG	low	Val158Met
TAS2R38	rs713598	CC	low	PAV/AVI
OR6A2	rs72921001	CC	low	Cilantro perception
OR2M7	rs4481887	GG	low	Asparagus metabolite
ABCC11	rs17822931	CT	low	Earwax type
LCT	rs4988235	GG	low	Lactase persistence
IL6	rs1800795	GG	low	-174G>C
SORT1		TT	low	SORT1 - LDL cholesterol
SORT1		GG	low	SORT1 - hepatic LDL uptake
PCSK9		TT	low	PCSK9 - cholesterol
HNF4A		CC	low	HNF4A - HDL
FADS1		TT	low	FADS1 - PUFA conversion

Cancer Genes 13

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Gene	rsID	Genotype	Severity	Description
BRCA1	rs80357906	DD	high	5382insC
BRCA2	rs80359550	II	high	6174delT
MLH1	rs63750447	TT	high	Lynch
CHEK2	rs17879961	AA	moderate	I157T
MSMB	rs10993994	CT	risk	Prostate risk
LSP1	rs3817198	CC	risk	Breast risk
SMAD7	rs4939827	CT	risk	CRC risk
TERT	rs2736100	CC	risk	Lung cancer
FOXE1	rs965513	AG	risk	Thyroid cancer
8q24	rs9642880	GT	risk	Bladder cancer
MUTYH	rs34612342	TT	carrier	Y179C
MUTYH	rs36053993	CC	carrier	G396D
KLK3	rs2735839	GG	info	PSA levels

Rare Variants 12

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Gene	rsID	Genotype	Severity	Description
HFE	rs1800562	GG	low	C282Y - iron overload
HFE	rs1799945	CC	low	H63D - iron accumulation
ATP7B	rs76151636	GG	low	Copper accumulation
MEFV	rs61752717	TT	low	M694V - Mediterranean
HBB	rs33930165	CC	low	Codon 39 nonsense
LDLR	rs28942078	GG	low	Very high LDL
APOB	rs5742904	CC	low	R3500Q - high LDL
PCSK9	rs11591147	GG	low	Loss of function - LOW LDL (protective)
G6PD	rs1050828	C	low	A- variant (African)
G6PD	rs5030868	G	low	Severe deficiency
PAH	rs5030858	GG	low	R408W - classic PKU
PRNP	rs1799990	AA	low	M129V - prion disease modifier

Clinvar 11

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Gene	rsID	Genotype	Severity	Description
BRCA1	rs80357906	DD	high	5382insC
BRCA2	rs80359550	II	high	6174delT
LDLR	rs28942078	GG	high	FH variant
SERPINA1	rs17580	TT	moderate	S allele
MEFV	rs28940580	CC	moderate	M680I
LCT	rs4988235	GG	moderate	Lactase persistence
COL3A1	rs2228241	GG	moderate	EDS proxy
SCN4A	rs1805124	TT	moderate	T704M proxy
ALDOB	rs1800546	CC	carrier	A149P
HBB	rs33930165	CC	carrier	IVS-I-110
GJB2	rs72474224	CC	carrier	167delT

All Trait Analysis

518 traits across 12 analysis phases

518

Nutrigenomics 66 10 significant

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Gene	rsID	Genotype	Result	Trait	Description
BCMO1	rs12934922	AT	Carrier	Vitamin A	Poor beta-carotene to retinol conversion (57% reduced)
BCMO1	rs7501331	CC	Typical	Vitamin A	Reduced carotenoid conversion
BCMO1	rs6564851	GT	Carrier	Vitamin A	Beta-carotene conversion impaired
NBPF3	rs4654748	CC	Typical	Vitamin B6	Lower B6 levels
ALPL	rs1256335	AG	Typical	Vitamin B6	Alkaline phosphatase - B6 metabolism
FUT2	rs602662	AG	Carrier	Vitamin B12	Non-secretor - lower B12 absorption
FUT2	rs601338	AG	Carrier	Vitamin B12	Non-secretor status
TCN2	rs1801198	GG	Significant	Vitamin B12	Transcobalamin - B12 transport impaired
TCN1	rs526934	AG	Carrier	Vitamin B12	B12 binding protein
MTHFR	rs1801133	AG	Typical	Folate	C677T - 30-70% reduced enzyme activity
MTHFR	rs1801131	TT	Typical	Folate	A1298C - reduced activity
SLC19A1	rs1051266	CT	Typical	Folate	RFC1 - folate transport reduced
MTHFD1	rs2236225	AG	Carrier	Folate	Folate metabolism
MTHFR	rs2274976	CC	Typical	Folate	Additional MTHFR variant
GC	rs2282679	TT	Typical	Vitamin D	Vitamin D binding protein - lower levels
GC	rs7041	CC	Typical	Vitamin D	DBP variant - reduced transport
VDR	rs2228570	AG	Typical	Vitamin D	FokI - vitamin D receptor
VDR	rs1544410	CT	Typical	Vitamin D	BsmI - VDR expression
APOA5	rs12272004	CC	Significant	Vitamin E	Vitamin E transport
ZNF259	rs964184	CG	Carrier	Vitamin E	Lipid metabolism - E transport
VKORC1	rs9923231	CC	Typical	Vitamin K	Vitamin K recycling - may need more K
VKORC1	rs2359612	GG	Typical	Vitamin K	VKORC1 haplotype
HFE	rs1800562	GG	Typical	Iron	C282Y - iron overload risk
HFE	rs1799945	CC	Typical	Iron	H63D - mild iron accumulation
TMPRSS6	rs855791	GG	Significant	Iron	Lower iron/hemoglobin levels
TMPRSS6	rs4820268	AA	Typical	Iron	Iron deficiency risk
SLC30A8	rs11558471	AA	Significant	Zinc	Zinc transporter - diabetes link
SLC30A8	rs13266634	CC	Significant	Zinc	ZnT8 - zinc in pancreas
TRPM6	rs2274924	CT	Carrier	Magnesium	Hypomagnesemia risk
CASR	rs1801725	GG	Typical	Calcium	Calcium sensing receptor
LCT	rs4988235	GG	Significant	Calcium	Lactose intolerance - affects calcium from dairy
FADS1	rs174546	CC	Typical	Omega-3	Reduced ALA to EPA conversion
FADS2	rs174575	CC	Significant	Omega-3	Reduced EPA/DHA synthesis
FADS2	rs1535	AA	Significant	Omega-3	Need preformed EPA/DHA
ELOVL2	rs953413	AG	Carrier	Omega-3	DHA elongation impaired
PEMT	rs7946	TT	Significant	Choline	Increased choline requirement
CYP1A2	rs762551	AA	Typical	Caffeine	Slow caffeine metabolizer
CYP1A2	rs2472297	CC	Typical	Caffeine	Caffeine metabolism rate
ALDH2	rs671	GG	Typical	Alcohol	Asian flush - acetaldehyde buildup
ADH1B	rs1229984	CC	Typical	Alcohol	Fast alcohol metabolism
HLA-DQ2.5	rs2187668	CC	Typical	Gluten	Celiac disease risk
HLA-DQ8	rs7454108	TT	Typical	Gluten	Celiac disease risk
ABP1/AOC1	rs10156191	CC	Typical	Histamine	DAO - histamine degradation reduced
ABP1/AOC1	rs1049793	CC	Typical	Histamine	Diamine oxidase variant
CBS	rs234706	AG	Carrier	Sulfur	CBS upregulation - sulfur sensitivity
CBS	rs1801181	GG	Typical	Sulfur	Sulfur metabolism
AGXT	rs34116584	CC	Typical	Oxalates	Glyoxylate metabolism - oxalate issues
AGT	rs699	AG	Typical	Salt	Angiotensinogen - salt-sensitive BP
ADD1	rs4961	GT	Carrier	Salt	Alpha-adducin - salt sensitivity
AGTR1	rs5186	AA	Typical	Salt	AT1 receptor - salt-sensitive hypertension
APOA5	rs662799	AG	Typical	Saturated Fat	Triglycerides spike with sat fat
GCKR	rs1260326	CT	Carrier	Carbs/Fat	Glucokinase - metabolic response
GCKR	rs780094	CT	Carrier	Carbs	Fasting glucose/triglycerides
TAS2R38	rs713598	CC	Significant	Bitter	PAV - supertaster (bitter sensitive)
TAS2R38	rs1726866	AG	Carrier	Bitter	Taster status
TAS2R38	rs10246939	CT	Carrier	Bitter	PTC/PROP tasting
TCN2		GG	Typical	Vitamin B12	Transcobalamin - B12 transport impaired
APOA5		CC	Typical	Vitamin E	Vitamin E transport
TMPRSS6		GG	Typical	Iron	Lower iron/hemoglobin levels
SLC30A8		AA	Typical	Zinc	Zinc transporter - diabetes link
SLC30A8		CC	Typical	Zinc	ZnT8 - zinc in pancreas
LCT		GG	Typical	Calcium	Lactose intolerance - affects calcium from dairy
FADS2		CC	Typical	Omega-3	Reduced EPA/DHA synthesis
FADS2		AA	Typical	Omega-3	Need preformed EPA/DHA
PEMT		TT	Typical	Choline	Increased choline requirement
TAS2R38		CC	Typical	Bitter	PAV - supertaster (bitter sensitive)

Detox 61 1 significant

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Gene	rsID	Genotype	Result	Trait	Description
CYP1A2	rs762551	AA	Typical	detox	Slow caffeine/drug metabolism
CYP1A2	rs2069526	GT	Typical	detox	CYP1A2*1F - inducibility
CYP1A1	rs1048943	CT	Carrier	detox	CYP1A1*2C - estrogen metabolism, cancer
CYP1B1	rs1056836	GG	Typical	detox	CYP1B1*3 - estrogen 4-hydroxylation (toxic)
CYP1B1	rs10012	CG	Carrier	detox	CYP1B1 - carcinogen activation
CYP2C9	rs1799853	CC	Typical	detox	CYP2C9*2 - warfarin, NSAIDs
CYP2C9	rs1057910	AC	Carrier	detox	CYP2C9*3 - reduced drug metabolism
CYP2C19	rs4244285	AG	Carrier	detox	CYP2C19*2 - poor metabolizer
CYP2C19	rs4986893	GG	Typical	detox	CYP2C19*3 - poor metabolizer
CYP2D6	rs3892097	CC	Typical	detox	CYP2D6*4 - poor metabolizer
CYP2D6	rs1065852	GG	Typical	detox	CYP2D6*10 - reduced activity
CYP3A5	rs776746	CT	Carrier	detox	CYP3A5*3 - non-expressor
CYP3A4	rs2740574	TT	Typical	detox	CYP3A4*1B - reduced activity
GSTP1	rs1695	AA	Typical	detox	GSTP1 Ile105Val - reduced detox
GSTP1	rs1138272	CC	Typical	detox	GSTP1 Ala114Val - substrate specificity
GSTA1	rs1799735	II	Typical	detox	GSTA1*B - reduced expression
GSTM1	rs1056806	CT	Typical	detox	GSTM1 null - no enzyme activity
UGT1A1	rs887829	CT	Carrier	detox	UGT1A1*80 - Gilbert's, bilirubin
NAT2	rs1801280	CT	Carrier	detox	NAT2*5 - slow acetylator
NAT2	rs1799930	GG	Typical	detox	NAT2*6 - slow acetylator
NAT2	rs1799931	GG	Typical	detox	NAT2*7 - slow acetylator
NAT2	rs1041983	CC	Typical	detox	NAT2 - acetylation status
COMT	rs4680	AG	Carrier	detox	COMT Val158Met - catechol estrogen clearance
CBS	rs234706	AG	Carrier	detox	CBS C699T - upregulation, sulfur sensitivity
CBS	rs1801181	GG	Typical	detox	CBS A360A - sulfur processing
ALAD	rs1800435	CC	Significant	detox	ALAD - lead susceptibility
TPMT	rs1800460	CC	Typical	detox	TPMT - thiopurine toxicity
TPMT	rs1142345	TT	Typical	detox	TPMT*3C - reduced activity
SOD2	rs4880	AG	Typical	detox	MnSOD - mitochondrial antioxidant
GPX1	rs1050450	AG	Typical	detox	GPX1 Pro198Leu - selenium response
GCLM	rs2301022	CC	Typical	detox	GCL modifier - glutathione production
NFE2L2	rs6721961	GG	Typical	detox	Nrf2 - master antioxidant switch
NFE2L2	rs1806649	CT	Carrier	detox	Nrf2 expression
ALDH2	rs671	GG	Typical	detox	ALDH2*2 - Asian flush, acetaldehyde buildup
ADH1B	rs1229984	CC	Typical	detox	ADH1B*2 - fast alcohol to acetaldehyde
ADH1C	rs1693482	CT	Carrier	detox	ADH1C*1 - alcohol metabolism
ALAD		CC	Typical	detox	ALAD - lead susceptibility
CYP1A2		AA	Typical	detox
CYP1A2		GT	Typical	detox
CYP1B1		GG	Typical	detox
CYP2C9		CC	Typical	detox
CYP2C19		GG	Typical	detox
CYP2D6		CC	Typical	detox
CYP2D6		GG	Typical	detox
CYP3A4		TT	Typical	detox
GSTP1		AA	Typical	detox
GSTP1		CC	Typical	detox
GSTA1		II	Typical	detox
GSTM1		CT	Typical	detox
NAT2		GG	Typical	detox
NAT2		GG	Typical	detox
NAT2		CC	Typical	detox
CBS		GG	Typical	detox
TPMT		CC	Typical	detox
TPMT		TT	Typical	detox
SOD2		AG	Typical	detox
GPX1		AG	Typical	detox
GCLM		CC	Typical	detox
NFE2L2		GG	Typical	detox
ALDH2		GG	Typical	detox
ADH1B		CC	Typical	detox

Neurotransmitters 59 4 significant

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Gene	rsID	Genotype	Result	Trait	Description
COMT	rs4680	AG	Carrier	neurotransmitters	Val158Met - slow dopamine clearance (worrier)
COMT	rs4633	CT	Carrier	neurotransmitters	COMT haplotype - dopamine metabolism
COMT	rs6269	AG	Carrier	neurotransmitters	COMT activity modifier
DRD2/ANKK1	rs1800497	GG	Typical	neurotransmitters	Taq1A - reduced D2 receptors, addiction risk
DRD2	rs6277	AG	Typical	neurotransmitters	C957T - D2 receptor expression
MAOB	rs1799836	C	Typical	neurotransmitters	MAO-B - dopamine breakdown
MAOA	rs1137070	C	Typical	neurotransmitters	MAO-A warrior gene
TPH2	rs4570625	GG	Typical	neurotransmitters	Tryptophan hydroxylase - serotonin synthesis
DRD2	rs2283265	CC	Typical	neurotransmitters	D2 receptor intronic variant
DRD2	rs1076560	CC	Typical	neurotransmitters	D2 receptor splice variant
DRD3	rs6280	TT	Significant	neurotransmitters	Ser9Gly - D3 receptor affinity
DRD4	rs1800955	CT	Carrier	neurotransmitters	-521C>T - D4 receptor expression
DRD4	rs3758653	CC	Significant	neurotransmitters	D4 receptor novelty seeking
DAT1/SLC6A3	rs27072	CC	Typical	neurotransmitters	Dopamine transporter
DBH	rs463379	CG	Typical	neurotransmitters	Dopamine beta-hydroxylase
DBH	rs1611115	CC	Typical	neurotransmitters	DBH - dopamine to norepinephrine conversion
HTR2A	rs6313	GG	Typical	neurotransmitters	5-HT2A receptor - SSRI response poor
HTR2A	rs6311	CC	Typical	neurotransmitters	5-HT2A promoter - serotonin signaling
HTR2A	rs7997012	AA	Typical	neurotransmitters	SSRI response modifier
HTR2A	rs6314	GG	Typical	neurotransmitters	His452Tyr - receptor function
SLC6A4	rs25531	--	Typical	neurotransmitters	SERT - serotonin transporter (S-allele proxy)
SLC6A4	rs140700	CC	Typical	neurotransmitters	Serotonin transporter intron 2
SLC6A4	rs1042173	AA	Typical	neurotransmitters	SERT 3' UTR variant
HTR1A	rs6295	CG	Carrier	neurotransmitters	5-HT1A autoreceptor - anxiety, depression
TPH2	rs1386483	CT	Typical	neurotransmitters	TPH2 variant - serotonin production
GABRA2	rs211014	CC	Typical	neurotransmitters	GABA-A receptor alpha2 - anxiety, alcohol
GABRA2	rs279858	TT	Typical	neurotransmitters	Alcohol dependence risk
GABRA2	rs11503014	CC	Significant	neurotransmitters	GABA receptor - inhibition
GABRA6	rs3219151	CT	Carrier	neurotransmitters	GABA-A alpha6 - alcohol sensitivity
GAD2	rs3749034	AG	Typical	neurotransmitters	GAD65 - GABA synthesis
GRIN2B	rs1805502	AA	Typical	neurotransmitters	NMDA receptor NR2B subunit
GRIN2B	rs7301328	CG	Carrier	neurotransmitters	NMDA receptor - learning, memory
GRIN2A	rs1019385	AA	Significant	neurotransmitters	NMDA receptor NR2A - synaptic plasticity
GRM3	rs2267715	GG	Typical	neurotransmitters	Metabotropic glutamate receptor 3
SLC1A2	rs548294	CT	Carrier	neurotransmitters	EAAT2 glutamate transporter
SLC6A2	rs2242446	CT	Carrier	neurotransmitters	NET variant - NE reuptake
ADRA2A	rs1800544	CG	Carrier	neurotransmitters	Alpha-2A - ADHD, anxiety
ADRB1	rs1801253	CG	Carrier	neurotransmitters	Beta-1 adrenergic - heart rate, BP
ADRB2	rs1042713	AG	Carrier	neurotransmitters	Beta-2 - asthma, stress response
BCHE	rs1799807	TT	Typical	neurotransmitters	Butyrylcholinesterase - anesthesia risk
BCHE	rs1803274	CC	Typical	neurotransmitters	K-variant - prolonged paralysis risk
CHRNA3	rs165599	AG	Carrier	neurotransmitters	Nicotinic receptor - nicotine dependence
CHRNA5	rs16969968	GG	Typical	neurotransmitters	Nicotinic receptor alpha5 - smoking addiction
CHRNA3	rs578776	AG	Carrier	neurotransmitters	Nicotine response
FAAH	rs324420	CC	Typical	neurotransmitters	Fatty acid amide hydrolase - pain, anxiety
CNR1	rs2023239	--	Typical	neurotransmitters	Cannabinoid receptor 1
CNR1	rs806368	CT	Typical	neurotransmitters	CB1 receptor expression
OPRM1	rs1799971	AA	Typical	neurotransmitters	Mu-opioid receptor - pain response, addiction
OPRM1	rs563649	CC	Typical	neurotransmitters	Opioid receptor variant
OPRD1	rs1042114	TT	Typical	neurotransmitters	Delta-opioid receptor
OPRD1	rs2236857	CT	Typical	neurotransmitters	Pain sensitivity, reward
BDNF	rs6265	CC	Typical	neurotransmitters	Val66Met - memory, neuroplasticity, depression
BDNF	rs7124442	CT	Carrier	neurotransmitters	BDNF expression
IL6	rs1800795	GG	Typical	neurotransmitters	-174G>C - brain inflammation
TNF	rs1800629	GG	Typical	neurotransmitters	TNF-alpha - neuroinflammation
DRD3		TT	Typical	neurotransmitters	Ser9Gly - D3 receptor affinity
DRD4		CC	Typical	neurotransmitters	D4 receptor novelty seeking
GABRA2		CC	Typical	neurotransmitters	GABA receptor - inhibition
GRIN2A		AA	Typical	neurotransmitters	NMDA receptor NR2A - synaptic plasticity

Hormones 48 6 significant

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Gene	rsID	Genotype	Result	Trait	Description
SHBG	rs6258	CC	Typical	hormones	Lower SHBG = higher free testosterone
SHBG	rs1799941	GG	Typical	hormones	SHBG levels - testosterone binding
SHBG	rs727428	CT	Typical	hormones	SHBG concentration
SHBG	rs12150660	GG	Typical	hormones	Free testosterone levels
CYP19A1	rs10046	AG	Typical	hormones	Aromatase - T to estrogen conversion
CYP19A1	rs2470152	AG	Typical	hormones	Estrogen synthesis from testosterone
ESR1	rs9340799	AG	Carrier	hormones	Estrogen receptor alpha - XbaI
ESR1	rs2234693	CT	Carrier	hormones	Estrogen receptor - PvuII
ESR2	rs3020450	CC	Typical	hormones	Estrogen receptor beta
CYP17A1	rs1801132	CC	Significant	hormones	Estrogen/androgen synthesis
CYP17A1	rs743572	AG	Typical	hormones	Steroid hormone synthesis
COMT	rs4680	AG	Carrier	hormones	Estrogen detoxification (slower)
CYP1B1	rs1056836	GG	Typical	hormones	4-OH estrogen pathway (more toxic)
CYP1A1	rs1048943	CT	Carrier	hormones	Estrogen metabolism
CYP1A2	rs762551	AA	Typical	hormones	2-OH estrogen pathway
NR3C1	rs6189	CC	Typical	hormones	Cortisol sensitivity
NR3C1	rs6190	CC	Typical	hormones	N363S - cortisol hypersensitivity
FKBP5	rs1360780	CC	Typical	hormones	Cortisol binding protein - PTSD risk
FKBP5	rs3800373	AA	Significant	hormones	GR sensitivity
FADS1	rs174537	GG	Typical	hormones	Inflammation-cortisol link
FOXE1	rs965513	AG	Carrier	hormones	Thyroid cancer/dysfunction risk
NKX2-1	rs944289	CC	Typical	hormones	Thyroid development
FOXE1	rs7850258	AG	Carrier	hormones	Thyroid function
DIO2	rs225014	CT	Carrier	hormones	T4 to T3 conversion impaired
DIO2	rs12885300	CT	Carrier	hormones	Deiodinase 2 - thyroid conversion
DIO1	rs2235544	CC	Typical	hormones	Deiodinase 1 - thyroid hormone activation
TCF7L2	rs7903146	CT	Carrier	hormones	Major diabetes gene - insulin secretion
TCF7L2	rs12255372	GT	Carrier	hormones	Beta cell function
KCNJ11	rs5219	TT	Significant	hormones	Potassium channel - insulin release
SLC30A8	rs13266634	CC	Significant	hormones	Zinc transporter - insulin storage
PPARG	rs1801282	CC	Significant	hormones	Pro12Ala - insulin sensitivity
FTO	rs8050136	CC	Typical	hormones	Obesity/insulin resistance
MTNR1B	rs10830963	CG	Carrier	hormones	Melatonin receptor - glucose
GH1	rs2665802	AA	Significant	hormones	Growth hormone production
GHR	rs6180	AC	Carrier	hormones	GH receptor - IGF-1 response
IGF1R	rs2229765	AG	Carrier	hormones	IGF-1 receptor
PRL	rs1341239	AC	Typical	hormones	Prolactin production
OXTR	rs53576	AG	Carrier	hormones	Oxytocin receptor - social bonding
OXTR	rs2254298	GG	Typical	hormones	Empathy, stress resilience
OXTR	rs1042778	GT	Carrier	hormones	Oxytocin sensitivity
PGR	rs1042838	CC	Typical	hormones	Progesterone receptor
PGR	rs10895068	CC	Typical	hormones	Progesterone response
CYP17A1		CC	Typical	hormones	Estrogen/androgen synthesis
FKBP5		AA	Typical	hormones	GR sensitivity
KCNJ11		TT	Typical	hormones	Potassium channel - insulin release
SLC30A8		CC	Typical	hormones	Zinc transporter - insulin storage
PPARG		CC	Typical	hormones	Pro12Ala - insulin sensitivity
GH1		AA	Typical	hormones	Growth hormone production

Aging 41 8 significant

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Gene	rsID	Genotype	Result	Trait	Description
TERT	rs2736100	CC	Significant	Telomeres	Telomerase - shorter telomeres, cancer risk
TERC	rs10936599	CT	Carrier	Telomeres	Telomerase RNA - telomere length
TERC	rs1317082	AG	Carrier	Telomeres	TERC - telomere length regulation
TERT	rs2853669	AG	Typical	Telomeres	TERT promoter - telomerase expression
TERT	rs2735940	AA	Typical	Telomeres	Telomere length variation
FOXO3	rs2802292	TT	Typical	Longevity	FOXO3 - centenarian gene, stress resistance
FOXO3	rs2764264	TT	Typical	Longevity	FOXO3 - autophagy, longevity
FOXO3	rs13217795	TT	Significant	Longevity	FOXO3 haplotype - longevity
FOXO3	rs2802290	AA	Typical	Longevity	FOXO3 - insulin/IGF signaling
APOE	rs7412	CC	Typical	Longevity	APOE ε2 - longevity, lower CVD/Alzheimer's
APOE	rs429358	TT	Typical	Longevity	APOE ε4 - reduced longevity, Alzheimer's
TOMM40	rs2075650	AA	Typical	Longevity	Mitochondrial import - cognitive aging
TP53	rs1042522	CG	Carrier	Longevity	p53 Pro72Arg - cancer vs aging tradeoff
TNF	rs1800629	GG	Typical	Longevity	TNF-alpha - inflammaging
XRCC1	rs25487	CC	Typical	DNA Repair	XRCC1 Arg399Gln - repair efficiency
ERCC1	rs3212986	CC	Typical	DNA Repair	Nucleotide excision repair
XPA	rs1800975	CC	Typical	DNA Repair	Xeroderma pigmentosum A - UV repair
ERCC2/XPD	rs238406	GG	Typical	DNA Repair	Nucleotide excision repair
ERCC2/XPD	rs13181	GG	Typical	DNA Repair	XPD Lys751Gln - DNA repair capacity
MLH1	rs1800734	AA	Significant	DNA Repair	Mismatch repair - Lynch syndrome
SOD2	rs4880	AG	Typical	Oxidative Stress	MnSOD Ala16Val - mitochondrial ROS
GSTP1	rs1695	AA	Typical	Oxidative Stress	Glutathione S-transferase - detox
HMOX1	rs7943316	AA	Typical	Oxidative Stress	Heme oxygenase 1 - antioxidant
HMOX1	rs2071746	TT	Typical	Oxidative Stress	HO-1 promoter - oxidative defense
CYBA	rs4673	AG	Typical	Oxidative Stress	p22phox - NADPH oxidase, ROS production
ATG16L1	rs2241880	AA	Typical	Autophagy	Autophagy - cellular cleanup, Crohn's
BECN1	rs10512488	GG	Typical	Autophagy	Beclin 1 - autophagy initiation
ULK1	rs3745274	GG	Typical	Autophagy	ULK1 - autophagy kinase
MTOR	rs2295080	GT	Carrier	mTOR	mTOR promoter - growth/aging balance
IRS1	rs1801278	CC	Typical	Insulin/IGF	Insulin receptor substrate - longevity
IGF1R	rs2229765	AG	Carrier	Insulin/IGF	IGF-1 receptor - growth/longevity tradeoff
CLOCK	rs1801260	AA	Typical	Circadian/Aging	CLOCK - circadian rhythm, aging
BMAL1	rs2278749	CC	Typical	Circadian/Aging	BMAL1 - circadian, metabolism, aging
IL6	rs1800795	GG	Typical	Inflammaging	-174G>C - chronic inflammation
IL1B	rs16944	AA	Significant	Inflammaging	IL-1B - inflammaging driver
IL10	rs1800896	TT	Typical	Inflammaging	IL-10 - anti-inflammatory (protective)
CRP	rs1205	CC	Typical	Inflammaging	C-reactive protein - inflammation marker
TERT	rs2736100	CC	Significant	Telomeres	Telomerase - shorter telomeres, cancer risk
FOXO3	rs13217795	TT	Significant	Longevity	FOXO3 haplotype - longevity
MLH1	rs1800734	AA	Significant	DNA Repair	Mismatch repair - Lynch syndrome
IL1B	rs16944	AA	Significant	Inflammaging	IL-1B - inflammaging driver

Athletic 40 3 significant

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Gene	rsID	Genotype	Result	Trait	Description
ACTN3	rs1815739	CT	Carrier	Muscle Fiber	R577X - XX = endurance, RR = power/sprint
PPARGC1A	rs8192678	TT	Typical	Muscle Fiber	PGC-1alpha Gly482Ser - muscle metabolism
PPARD	rs2016520	TT	Typical	Endurance	PPAR-delta - endurance capacity
ADRB3	rs4994	AA	Typical	Endurance	Beta-3 receptor - fat burning
ADRB2	rs1042713	AG	Carrier	Endurance	Beta-2 receptor - bronchodilation
ADRB2	rs1042714	CC	Typical	Endurance	ADRB2 Gln27Glu - asthma/exercise
HIF1A	rs11549465	CC	Typical	Endurance	Pro582Ser - oxygen sensing
NOS3	rs2070744	TT	Typical	Endurance	eNOS promoter - nitric oxide
PPARA	rs1800206	CC	Significant	Endurance	Fatty acid oxidation
AMPD1	rs17602729	GG	Typical	Power	AMP deaminase - muscle energy
CNTF	rs1800169	AG	Carrier	Power	Ciliary neurotrophic factor - muscle mass
VEGFA	rs6552828	GG	Significant	VO2max	VEGF - angiogenesis, VO2max trainability
VEGFA	rs2010963	CG	Carrier	VO2max	VEGF expression - capillary density
VEGFA	rs3025039	CC	Typical	VO2max	VEGF 3' UTR - endurance response
VEGFA	rs833061	TT	Significant	VO2max	VEGF promoter
IL6	rs1800795	GG	Typical	Recovery	-174G>C - inflammation/recovery
TNF	rs1800629	GG	Typical	Recovery	TNF-alpha - muscle damage response
IL10	rs1800896	TT	Typical	Recovery	IL-10 - anti-inflammatory recovery
SOD2	rs4880	AG	Typical	Recovery	MnSOD - oxidative stress from exercise
SOD1	rs2070424	AG	Carrier	Recovery	Cu/Zn SOD - muscle recovery
COL5A1	rs12722	CC	Typical	Injury	Type V collagen - tendon/ligament strength
COL1A1	rs1800012	CC	Typical	Injury	Type I collagen - bone stress fractures
COL1A1	rs1107946	CC	Typical	Injury	Collagen I - ACL injury risk
GDF5	rs143383	GG	Typical	Injury	Growth differentiation factor - Achilles risk
COL12A1	rs970547	CC	Typical	Injury	Type XII collagen - anterior cruciate ligament
MMP3	rs679620	TT	Typical	Injury	MMP-3 - tendinopathy risk
APOE	rs7412	CC	Typical	Supplements	APOE - response to creatine
APOE	rs429358	TT	Typical	Supplements	APOE ε4 - creatine/concussion risk
CYP1A2	rs762551	AA	Typical	Caffeine	Caffeine metabolism - ergogenic effect
AHR	rs4410790	CC	Typical	Caffeine	Caffeine consumption tendency
COMT	rs4680	AG	Carrier	Pain	Val158Met - pain tolerance
SCN9A	rs6746030	GG	Typical	Pain	Nav1.7 sodium channel - pain sensitivity
SHBG	rs6258	CC	Typical	Hormones	Sex hormone binding globulin - free testosterone
SHBG	rs1799941	GG	Typical	Hormones	SHBG levels - testosterone availability
SHBG	rs12150660	GG	Typical	Hormones	Free testosterone
CYP19A1	rs10046	AG	Typical	Hormones	Aromatase - testosterone to estrogen
ADRB1	rs1801253	CG	Carrier	Cardiac	Beta-1 receptor - heart rate response
PPARA		CC	Typical	Endurance	Fatty acid oxidation
VEGFA		GG	Typical	VO2max	VEGF - angiogenesis, VO2max trainability
VEGFA		TT	Typical	VO2max	VEGF promoter

Pain 40 5 significant

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Gene	rsID	Genotype	Result	Trait	Description
OPRM1	rs1799971	AA	Typical	Opioid Response	Mu-opioid receptor A118G - reduced opioid effect
OPRM1	rs563649	CC	Typical	Opioid Response	OPRM1 - opioid sensitivity
OPRD1	rs1042114	TT	Typical	Opioid Response	Delta-opioid receptor - pain/reward
OPRD1	rs2236857	CT	Typical	Opioid Response	OPRD1 - pain perception
SCN9A	rs6746030	GG	Typical	Pain Perception	Nav1.7 - pain sensitivity (A=more sensitive)
SCN10A	rs12994338	CC	Typical	Pain Perception	Nav1.8 - peripheral pain
SCN10A	rs6795970	AA	Significant	Pain Perception	SCN10A - nociceptive signaling
COMT	rs4680	AG	Carrier	Pain Sensitivity	Val158Met - Met/Met = higher pain sensitivity
COMT	rs4633	CT	Carrier	Pain Sensitivity	COMT haplotype - pain processing
COMT	rs6269	AG	Carrier	Pain Sensitivity	COMT - dopamine/pain link
COMT	rs165774	AG	Carrier	Pain Sensitivity	COMT haplotype - fibromyalgia risk
TRPV1	rs8065080	TT	Significant	Heat Pain	TRPV1 I585V - thermal pain sensitivity
TRPV1	rs224534	AA	Typical	Heat Pain	TRPV1 T469I - pain threshold
GCH1	rs8007267	CT	Typical	Pain Protection	GCH1 - reduced chronic pain risk
GCH1	rs3783641	AT	Carrier	Pain Protection	GCH1 haplotype - pain protective
TNF	rs1800629	GG	Typical	Chronic Pain	TNF-alpha - inflammatory pain
IL1B	rs1143634	GG	Typical	Chronic Pain	IL-1B - inflammatory pain
IL1B	rs16944	AA	Significant	Chronic Pain	IL-1B promoter - pain inflammation
PRDM16	rs2651899	CT	Carrier	Migraine	PRDM16 - migraine susceptibility
TRPM8	rs10166942	TT	Significant	Migraine	TRPM8 - migraine (cold receptor)
LRP1	rs11172113	CT	Carrier	Migraine	LRP1 - migraine with aura
MTDH	rs1835740	CT	Carrier	Migraine	MTDH - migraine risk
TGFBR2	rs6790925	TT	Significant	Migraine	TGF-beta receptor - migraine
MEF2D	rs2274316	AC	Carrier	Migraine	MEF2D - migraine susceptibility
HTR2A	rs6311	CC	Typical	Fibromyalgia	5-HT2A promoter - fibromyalgia
HTR2A	rs6313	GG	Typical	Fibromyalgia	HTR2A - fibromyalgia/pain
TPH2	rs4570625	GG	Typical	Fibromyalgia	TPH2 - serotonin/fibromyalgia
P2RX7	rs2227551	GT	Typical	Neuropathic Pain	P2X7 receptor - chronic/neuropathic pain
P2RX7	rs3751143	AA	Typical	Neuropathic Pain	P2RX7 Glu496Ala - pain processing
FAAH	rs324420	CC	Typical	Cannabinoid	FAAH C385A - reduced pain, less anxiety
CNR1	rs2023239	--	Typical	Cannabinoid	CB1 receptor - pain modulation
CNR1	rs1049353	CT	Typical	Cannabinoid	CNR1 - endocannabinoid pain
ABCB1	rs1128503	AA	Typical	Drug Response	P-glycoprotein - opioid brain penetration
ABCB1	rs1045642	AG	Typical	Drug Response	ABCB1 C3435T - analgesic efficacy
PDYN	rs6912029	GG	Typical	Endogenous Opioids	Prodynorphin - endogenous pain modulation
SCN10A		AA	Typical	Pain Perception	SCN10A - nociceptive signaling
TRPV1		TT	Typical	Heat Pain	TRPV1 I585V - thermal pain sensitivity
IL1B		AA	Typical	Chronic Pain	IL-1B promoter - pain inflammation
TRPM8		TT	Typical	Migraine	TRPM8 - migraine (cold receptor)
TGFBR2		TT	Typical	Migraine	TGF-beta receptor - migraine

Methylation 38 7 significant

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Gene	rsID	Genotype	Result	Trait	Description
MTHFR	rs1801133	AG	Typical	methylation	C677T - 30-70% reduced activity
MTHFR	rs1801131	TT	Typical	methylation	A1298C - ~20% reduced activity
MTHFR	rs2274976	CC	Typical	methylation	R594Q - additional MTHFR variant
SLC19A1/RFC1	rs1051266	CT	Typical	methylation	Reduced folate carrier - transport
MTHFD1	rs2236225	AG	Carrier	methylation	R653Q - folate metabolism
MTHFD1	rs1476413	CC	Typical	methylation	Folate pool balance
ALPL	rs1256335	AG	Typical	methylation	Alkaline phosphatase - B6 to P5P
NBPF3	rs4654748	CC	Typical	methylation	B6 blood levels
MTR	rs1805087	GG	Significant	methylation	A2756G - methionine synthase
MTRR	rs1801394	AG	Carrier	methylation	A66G - MTR reductase, B12 recycling
MTRR	rs10380	CC	Significant	methylation	MTRR variant - B12 regeneration
MTRR	rs1802059	AG	Carrier	methylation	MTRR - vitamin B12 metabolism
MTRR	rs162036	AA	Typical	methylation	MTRR K350A - B12 utilization
BHMT	rs3733890	AG	Carrier	methylation	R239Q - homocysteine remethylation
BHMT	rs651852	CT	Carrier	methylation	BHMT expression
PEMT	rs7946	TT	Significant	methylation	Choline requirement increased
CBS	rs234706	AG	Carrier	methylation	C699T - CBS upregulation
CBS	rs1801181	GG	Typical	methylation	A360A - CBS activity
CBS	rs2851391	TT	Significant	methylation	CBS promoter
CTH	rs4920037	AG	Carrier	methylation	Cystathionine gamma-lyase - H2S
FUT2	rs602662	AG	Carrier	methylation	Non-secretor - reduced B12 absorption
FUT2	rs601338	AG	Carrier	methylation	Non-secretor status
TCN2	rs1801198	GG	Significant	methylation	Transcobalamin II - B12 delivery
TCN1	rs526934	AG	Carrier	methylation	Transcobalamin I - B12 binding
AHCY	rs2993763	AG	Typical	methylation	S-adenosylhomocysteine hydrolase
DNMT1	rs2228611	CT	Typical	methylation	DNA methyltransferase 1 - maintenance
DNMT3B	rs2424913	TT	Significant	methylation	DNMT3B - de novo methylation
DNMT3A	rs1569686	TT	Significant	methylation	DNMT3A - de novo methylation
COMT	rs4680	AG	Carrier	methylation	Val158Met - slow methylation, higher dopamine
COMT	rs4633	CT	Carrier	methylation	COMT haplotype
COMT	rs6269	AG	Carrier	methylation	COMT activity modifier
MTR		GG	Typical	methylation	A2756G - methionine synthase
MTRR		CC	Typical	methylation	MTRR variant - B12 regeneration
PEMT		TT	Typical	methylation	Choline requirement increased
CBS		TT	Typical	methylation	CBS promoter
TCN2		GG	Typical	methylation	Transcobalamin II - B12 delivery
DNMT3B		TT	Typical	methylation	DNMT3B - de novo methylation
DNMT3A		TT	Typical	methylation	DNMT3A - de novo methylation

Longevity Cognitive 38 7 significant

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Gene	rsID	Genotype	Result	Trait	Description
KLOTHO	rs9536314	TT	Significant	Longevity Extended	KL-VS - anti-aging hormone
IL6	rs1800795	GG	Typical	Longevity Extended	IL-6 - inflammatory aging
SIRT3	rs11555236	CC	Typical	Longevity Extended	Mitochondrial sirtuin - longevity
TP53	rs1042522	CG	Carrier	Longevity Extended	TP53 Arg72Pro - lifespan ~3yr difference
APOC3	rs2542052	AC	Carrier	Longevity Extended	APOC3 - lipid metabolism longevity
AKT1	rs3803304	CG	Carrier	Longevity Extended	PI3K-Akt pathway - lifespan
BPIFB4	rs2070325	AG	Carrier	Longevity Extended	LAV - longevity-associated variant
CETP	rs5882	AA	Typical	Longevity Extended	CETP - HDL/longevity
PON1	rs662	CC	Typical	Longevity Extended	Paraoxonase - oxidative stress protection
ADIPOQ	rs1501299	GG	Significant	Longevity Extended	Adiponectin - metabolic longevity
CISD2	rs1418258	CT	Carrier	Longevity Extended	CISD2 - mitochondrial longevity
KIBRA	rs17070145	CT	Carrier	Cognitive Function	KIBRA - episodic memory performance
BDNF	rs6265	CC	Typical	Cognitive Function	BDNF Val66Met - memory/neuroplasticity
COMT	rs4680	AG	Carrier	Cognitive Function	COMT Val158Met - working memory
CLU	rs11136000	CC	Typical	Cognitive Function	Clusterin - cognitive aging
PICALM	rs3851179	CC	Typical	Cognitive Function	PICALM - cognitive aging
SORL1	rs2282649	TT	Significant	Cognitive Function	SORL1 - memory sorting receptor
NRG1	rs35753505	CT	Carrier	Cognitive Function	Neuregulin 1 - cognition
DISC1	rs821616	TT	Significant	Cognitive Function	DISC1 - cognitive function
DTNBP1	rs2619522	AC	Typical	Cognitive Function	Dysbindin - general cognitive ability
TAS2R38	rs713598	CC	Significant	Taste/Smell/Sensory	TAS2R38 PAV - PTC bitter taster
TAS2R38	rs1726866	AG	Typical	Taste/Smell/Sensory	TAS2R38 - bitter taste sensitivity
TAS2R38	rs10246939	CT	Carrier	Taste/Smell/Sensory	TAS2R38 - PROP bitter perception
TAS1R1	rs34160967	GG	Significant	Taste/Smell/Sensory	Glutamate umami taste sensitivity
OR2M7	rs6591536	AG	Carrier	Taste/Smell/Sensory	Asparagus metabolite smell
OR6A2	rs72921001	CC	Typical	Taste/Smell/Sensory	Cilantro aversion (soap taste)
CNTNAP2	rs7794745	AA	Typical	Taste/Smell/Sensory	Language impairment/autism speech
KIAA0319	rs4504469	TT	Significant	Taste/Smell/Sensory	Dyslexia susceptibility
DCDC2	rs793862	GG	Typical	Taste/Smell/Sensory	Dyslexia GWAS
XPC	rs2228000	AG	Typical	Hearing / DNA Repair	Xeroderma pigmentosum - UV sensitivity
ERCC2	rs13181	GG	Typical	Hearing / DNA Repair	DNA repair - photosensitivity
KLOTHO		TT	Typical	Longevity Extended	KL-VS - anti-aging hormone
ADIPOQ		GG	Typical	Longevity Extended	Adiponectin - metabolic longevity
SORL1		TT	Typical	Cognitive Function	SORL1 - memory sorting receptor
DISC1		TT	Typical	Cognitive Function	DISC1 - cognitive function
TAS2R38		CC	Typical	Taste/Smell/Sensory	TAS2R38 PAV - PTC bitter taster
TAS1R1		GG	Typical	Taste/Smell/Sensory	Glutamate umami taste sensitivity
KIAA0319		TT	Typical	Taste/Smell/Sensory	Dyslexia susceptibility

Skin Eye Wound 37 4 significant

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Gene	rsID	Genotype	Result	Trait	Description
NLRP1	rs12150220	AA	Significant	Vitiligo	NLRP1 - vitiligo inflammasome
TYR	rs1126809	--	Typical	Vitiligo	TYR - vitiligo/melanoma
HLA-C	rs10484554	CT	Typical	Psoriasis Extended	HLA-C*06:02 - psoriasis
IL12B	rs3212227	GT	Typical	Psoriasis Extended	IL-12B - psoriasis pathway
IL23R	rs11209026	GG	Typical	Psoriasis Extended	IL-23R - psoriasis
TRAF3IP2	rs33980500	CC	Typical	Psoriasis Extended	TRAF3IP2 - IL-17/psoriasis
CTLA4	rs3087243	AA	Typical	Alopecia Areata	CTLA4 - alopecia areata
IL2RA	rs3118470	CT	Carrier	Alopecia Areata	IL2RA - T cell/alopecia
IKZF4	rs1701704	TT	Significant	Alopecia Areata	IKZF4 - alopecia GWAS
NEDD4	rs8032158	CT	Carrier	Wound Healing / Keloid	NEDD4 - keloid/TGF-beta
TGFB1	rs1800469	AG	Carrier	Wound Healing / Keloid	TGF-beta1 - fibrosis susceptibility
TGFB1	rs1800470	AG	Typical	Wound Healing / Keloid	TGF-beta1 - scarring
MMP1	rs1799750	DD	Typical	Wound Healing / Keloid	MMP1 - collagen degradation
COL1A1	rs1800012	CC	Typical	Wound Healing / Keloid	COL1A1 - scar formation
HIF1A	rs11549465	CC	Typical	Wound Healing / Keloid	HIF1A - wound hypoxia
VEGFA	rs2010963	CG	Carrier	Wound Healing / Keloid	VEGFA - wound vascularization
CTGF	rs9399005	CT	Typical	Wound Healing / Keloid	CTGF - connective tissue growth
SOD2	rs4880	AG	Carrier	Wound Healing / Keloid	SOD2 - oxidative stress/wound
CAV1	rs4236601	AG	Carrier	Glaucoma Extended	CAV1 - POAG glaucoma
TMCO1	rs4656461	AA	Typical	Glaucoma Extended	TMCO1 - intraocular pressure
CDKN2B	rs2157719	CT	Typical	Glaucoma Extended	9p21 - glaucoma
SIX6	rs10483727	TT	Typical	Glaucoma Extended	SIX6 - POAG GWAS
FNDC3B	rs4894535	CC	Typical	Keratoconus	FNDC3B - corneal thickness
COL5A1	rs1536482	AG	Carrier	Keratoconus	COL5A1 - corneal biomechanics
ZNF469	rs9938149	AA	Typical	Keratoconus	ZNF469 - brittle cornea
ARMS2	rs10490924	GG	Typical	AMD Extended	ARMS2/HTRA1 - AMD susceptibility
CFI	rs10033900	TT	Significant	AMD Extended	Complement factor I - AMD
CFB	rs641153	GG	Typical	AMD Extended	Complement factor B - AMD
TCF4	rs613872	TT	Significant	Corneal Dystrophy	TCF4 - Fuchs endothelial dystrophy
ZEB1	rs2273235	GT	Carrier	Corneal Dystrophy	ZEB1 - posterior polymorphous CD
ERCC2	rs13181	GG	Typical	Photosensitivity	ERCC2/XPD - DNA repair/photosensitivity
XPC	rs2228000	AG	Typical	Photosensitivity	XPC - UV sensitivity
MC1R	rs1805007	CC	Typical	Photosensitivity	MC1R R151C - UV damage
NLRP1		AA	Typical	Vitiligo	NLRP1 - vitiligo inflammasome
IKZF4		TT	Typical	Alopecia Areata	IKZF4 - alopecia GWAS
CFI		TT	Typical	AMD Extended	Complement factor I - AMD
TCF4		TT	Typical	Corneal Dystrophy	TCF4 - Fuchs endothelial dystrophy

Sleep 31 3 significant

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Gene	rsID	Genotype	Result	Trait	Description
NPSR1	rs12927162	AA	Typical	Chronotype	Evening preference
NPAS2	rs2653349	GG	Typical	Chronotype	Circadian rhythm - evening type
PER2	rs934945	TT	Typical	Chronotype	Period gene - sleep timing
PER2	rs2304672	GG	Typical	Chronotype	Evening chronotype
PER3	rs228697	CC	Significant	Chronotype	Morning lark tendency
CLOCK	rs1801260	AA	Typical	Chronotype	Evening preference, later bedtime
ADA	rs73598374	CC	Typical	Chronotype	Adenosine - sleep pressure
MTNR1B	rs10830963	CG	Carrier	Melatonin	Melatonin receptor - glucose/sleep link
MTNR1B	rs4753426	CT	Carrier	Melatonin	Melatonin receptor variant
BTBD9	rs3923809	AG	Carrier	Insomnia/RLS	Restless leg syndrome - sleep disruption
BTBD9	rs9357271	TT	Significant	Insomnia/RLS	Periodic limb movements
COMT	rs4680	AG	Carrier	Sleep Quality	Met/Met - worry, light sleep
DRD2/ANKK1	rs1800497	GG	Typical	Sleep Quality	Dopamine - sleep reward
BDNF	rs6265	CC	Typical	Sleep Quality	BDNF Val66Met - sleep architecture
HLA-DRB1	rs3129934	CC	Typical	Narcolepsy	Narcolepsy/hypocretin link
CYP1A2	rs762551	AA	Typical	Caffeine/Sleep	Slow caffeine metabolism - disrupts sleep
CYP1A2	rs2472297	CC	Typical	Caffeine/Sleep	Caffeine clearance rate
ADORA2A	rs5751876	CT	Carrier	Caffeine/Sleep	Adenosine receptor - caffeine sensitivity
PER1	rs1144566	CC	Typical	Shift Work	Circadian disruption sensitivity
NR1D1	rs2735611	AA	Typical	Shift Work	REV-ERB alpha - circadian reset
PER1	rs2640908	CC	Typical	Delayed Phase	Delayed sleep phase tendency
CRY1	rs1534891	CC	Typical	Delayed Phase	Cryptochrome - delayed sleep phase disorder
PER3		CC	Typical	Chronotype	Morning lark tendency
BTBD9		TT	Typical	Insomnia/RLS	Periodic limb movements
NPSR1	rs12927162	AA	Typical	Chronotype	Evening preference
NPAS2	rs2653349	GG	Typical	Chronotype	Circadian rhythm - evening type
PER2	rs934945	TT	Typical	Chronotype	Period gene - sleep timing
PER2	rs2304672	GG	Typical	Chronotype	Evening chronotype
PER3	rs228697	CC	Significant	Chronotype	Morning lark tendency
CLOCK	rs1801260	AA	Typical	Chronotype	Evening preference, later bedtime
ADA	rs73598374	CC	Typical	Chronotype	Adenosine - sleep pressure

Cognitive Neurodev 19 2 significant

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Gene	rsID	Genotype	Result	Trait	Description
KIBRA	rs17070145	CT	Carrier	Memory / Cognition	KIBRA/WWC1 - episodic memory performance
CLU	rs11136000	CC	Typical	Memory / Cognition	CLU/Clusterin - cognitive aging / AD risk
PICALM	rs3851179	CC	Typical	Memory / Cognition	PICALM - phosphatidylinositol / cognitive aging
NRG1	rs35753505	CT	Carrier	Cognition / Psychosis	NRG1/Neuregulin - cognition and psychosis risk
NRXN1	rs1045881	CC	Typical	Cognition / Synaptic	NRXN1 - synaptic adhesion / intellectual ability
DTNBP1	rs2619522	AC	Typical	Cognition / Synaptic	DTNBP1/Dysbindin - general cognitive ability
BDNF	rs6265	CC	Typical	Neuroplasticity	BDNF Val66Met - neuroplasticity / memory
SNAP25	rs3785143	CT	Carrier	ADHD / Synaptic	SNAP25 - synaptic vesicle / ADHD
CNTNAP2	rs7794745	AA	Typical	Autism / Language	CNTNAP2 - autism spectrum / language impairment
OXTR	rs2217262	AC	Carrier	Autism / Social	OXTR - oxytocin receptor / social behavior / ASD
OXTR	rs53576	AG	Carrier	Autism / Social	OXTR rs53576 - empathy / social cognition
OXTR	rs2254298	GG	Typical	Autism / Social	OXTR - ASD susceptibility / attachment
MET	rs1858830	CC	Significant	Autism / MET	MET receptor - autism / GI dysfunction
KLOTHO	rs9536314	TT	Significant	Cognitive Aging	KLOTHO KL-VS - cognitive longevity / neuroprotection
DRD1	rs6675281	CC	Typical	Dopamine / Cognition	DRD1 - dopamine receptor D1 / working memory
COMT	rs4680	AG	Carrier	Dopamine / Cognition	COMT Val158Met - prefrontal dopamine / executive function
COMT	rs165599	AG	Carrier	Dopamine / Cognition	COMT 3'UTR - schizophrenia / cognitive decline
MET		CC	Typical	Autism / MET	MET receptor - autism / GI dysfunction
KLOTHO		TT	Typical	Cognitive Aging	KLOTHO KL-VS - cognitive longevity / neuroprotection

All Pharmacogenomic Interactions

166 drug-gene interactions sorted by severity

166

Gene	rsID	Genotype	Drug	Effect	Severity
	rs67376798	TT	50% reduction	D949V	high
	rs55886062	AA	50% reduction	*13 (I560S)	high
ALDH2	rs671	GG	Alcohol	Asian flush / toxicity	moderate
DPYD*2A	rs3918290	CC	5-Fluorouracil	FATAL TOXICITY	moderate
DPYD	rs67376798	TT	5-Fluorouracil	Toxicity risk	moderate
TPMT*3C	rs1142345	TT	Azathioprine, 6-MP	Severe toxicity	moderate
CYP2C9*3	rs1057910	AC	Warfarin, NSAIDs, Phenytoin	Slow metabolizer	moderate
CYP2C19*2	rs4244285	AG	Clopidogrel, PPIs	Poor metabolizer - DRUG WON'T WORK	moderate
CYP2C19*3	rs4986893	GG	Clopidogrel	Poor metabolizer	moderate
CYP2D6*4	rs3892097	CC	Codeine, Tramadol, Tamoxifen	Poor metabolizer - drug won't work	moderate
HTR2A	rs7997012	AA	SSRIs	Poor SSRI response	moderate
ITGB3	rs5918	TT	Aspirin	Aspirin resistance	moderate
VKORC1	rs9923231	CC	Warfarin	Dose reduction needed	moderate
CYP2C9*2	rs1799853	CC	Warfarin, NSAIDs	Slow metabolizer	moderate
SLCO1B1*5	rs4149056	TT	Simvastatin, Atorvastatin	Myopathy risk	moderate
CYP2D6*10	rs1065852	GG	Codeine, Tramadol	Reduced function	moderate
OPRM1	rs1799971	AA	Opioids	Reduced response	moderate
TPMT*3B	rs1800460	CC	Azathioprine, 6-MP	Toxicity	moderate
CYP2C19*17	rs12248560	CC	Clopidogrel	Ultra-rapid - increased bleeding	moderate
SLCO1B1*1B	rs2306283	AG	Statins	Altered transport	moderate
HTR1A	rs6295	CG	SSRIs, Buspirone	Response variability	moderate
ADRB1	rs1801253	CG	Beta blockers (metoprolol, etc)	Response variability	moderate
SLC22A1	rs622342	AA	Metformin	Response variability	moderate
SLC19A1	rs1051266	CT	Methotrexate	Toxicity/response	moderate
CYP1A2	rs762551	AA	Caffeine	Fast metabolizer (A/A)	moderate
HLA-B*57:01	rs2395029	TT	Abacavir (HIV)	Abacavir hypersensitivity	moderate
HLA-A*31:01	rs2844682	GG	Carbamazepine	Carbamazepine hypersensitivity	moderate
HLA-B*15:02	rs1061235	AT	Carbamazepine, Phenytoin	SJS/TEN risk (Asian)	moderate
HLA-B*58:01	rs9263726	GG	Allopurinol	Allopurinol SJS risk	moderate
HLA-DQ2.5	rs2187668	CC	None	Celiac disease risk	moderate
HLA-DQ8	rs7454108	TT	None	Celiac disease risk	moderate
HLA-DQ2.5	rs2395182	TT	None	Celiac proxy #2	moderate
PTPN22	rs2476601	GG	None	Multiple autoimmune diseases	moderate
CTLA4	rs3087243	AA	None	Autoimmune thyroid, T1D, others	moderate
CTLA4	rs231775	AA	None	Autoimmune risk #2	moderate
IL2RA	rs2104286	TT	None	Multiple sclerosis, T1D risk	moderate
CTLA4	rs11571315	CC	None	Graves disease	moderate
PTPN2	rs2542151	GT	None	Type 1 diabetes risk	moderate
C12orf30	rs17696736	AA	None	Type 1 diabetes risk	moderate
HLA-DRB1*15:01	rs3135388	GG	None	Multiple sclerosis risk	moderate
HLA-DQB1	rs6457617	CT	None	RA risk	moderate
HLA-C*06:02	rs10484554	CT	None	Psoriasis risk	moderate
HLA-C	rs12191877	CT	None	Psoriasis proxy	moderate
IL23R	rs11209026	GG	None	IBD protective	moderate
ATG16L1	rs2241880	AA	None	Crohn's disease risk	moderate
IRGM	rs10065172	CC	None	Crohn's disease risk	moderate
NKX2-3	rs10883365	AG	None	IBD risk	moderate
IL10	rs1000113	CC	None	Ulcerative colitis	moderate
IL10	rs3024505	GG	None	UC risk #2	moderate
HLA-DRB1	rs1270942	AA	None	Lupus risk	moderate
IRF5	rs10488631	TT	None	Lupus risk	moderate
STAT4	rs7574865	GG	None	Lupus/RA risk	moderate
IL2RA	rs4648356	AC	None	MS risk	moderate
IL2/IL21	rs6822844	GG	None	Sjögren's, celiac, RA	moderate
HLA-DQB1*06:02	rs5770917	CT	None	Narcolepsy risk	moderate
IL6	rs1800795	GG	None	Inflammatory response	moderate
TNF-alpha	rs1800629	GG	None	Inflammatory response	moderate
IL1B	rs16944	AA	None	Inflammatory response	moderate
IL8	rs4073	TT	None	Inflammatory response	moderate
IFN-gamma	rs360719	AG	None	Immune response	moderate
*4	rs3892097	CC		non-functional	moderate
*10	rs1065852	GG		decreased function	moderate
*6	rs5030655	II		non-functional (deletion)	moderate
*2 (normal)	rs16947	AG		normal function	moderate
*2 (GC)	rs1135840	GG		normal function marker	moderate
*17	rs28371706	GG		decreased function	moderate
*41	rs28371725	CC		decreased function	moderate
*9	rs5030656	II		decreased function	moderate
*29	rs59421388	CC		decreased function	moderate
CYP2D6 promoter	rs1058164	CG		expression variation	moderate
	rs2297595	TT	25% reduction	M166V	moderate
	rs1800462	CC		non-functional	moderate
	rs1800460	CC		non-functional	moderate
	rs1142345	TT		non-functional	moderate
	rs12201199	AA		non-functional	moderate
	rs1800584	CC		decreased function	moderate
	rs4148323	GG		reduced activity	moderate
	rs10929302	AG		expression variation	moderate
	rs887829	CT		Gilbert's marker	moderate
	rs3755319	AC		expression	moderate
	rs2003569	GG		activity marker	moderate
	rs4149056	TT		severe myopathy risk	moderate
	rs2306283	AG		altered transport	moderate
	rs4149015	GG		activity marker	moderate
	rs11045819	CC		increased function	moderate
	rs34671512	AA		decreased function	moderate
	rs57040246	CC		decreased function	moderate
VKORC1	rs9923231	CC		unknown effect for CC	moderate
VKORC1	rs9934438	GG		unknown effect for GG	moderate
VKORC1	rs7294	CT		sensitivity marker	moderate
VKORC1	rs2359612	GG		sensitivity marker	moderate
CYP2C9	rs1799853	CC		normal	moderate
CYP2C9	rs1057910	AC		30% dose reduction	moderate
CYP2C9	rs28371686	CC		decreased function	moderate
CYP2C9	rs9332131	II		non-functional	moderate
CYP2C9	rs28371685	CC		decreased function	moderate
CYP4F2	rs2108622	CT		unknown effect for CT	moderate
	rs2395029	TT	Abacavir		moderate
	rs1061235	AT	Carbamazepine, Phenytoin, Oxcarbazepine		moderate
	rs2844682	GG	Carbamazepine		moderate
	rs9263726	GG	Allopurinol		moderate
	rs9277535	AG	Hepatitis B vaccine		moderate
	rs2523822	AG	Multiple		moderate
	rs7775228	TT	Ximelagatran		moderate
	rs9275319	AA	Lumiracoxib		moderate
CYP3A5	rs776746	CT		non-expressor - reduced tacrolimus metabolism	moderate
CYP3A5	rs10264272	CC		non-expressor	moderate
CYP3A5	rs41303343	II		non-expressor	moderate
CYP3A4	rs2740574	TT		possibly reduced expression	moderate
CYP3A4	rs4646437	AA		activity marker	moderate
	rs1801280	CT		slow acetylator	moderate
	rs1799930	GG		slow acetylator	moderate
	rs1799931	GG		slow acetylator	moderate
	rs1801279	GG		slow acetylator	moderate
	rs1208	AG		rapid acetylator marker	moderate
	rs1041983	CC		slow acetylator	moderate
	rs1495741	AG		acetylator status predictor	moderate
	rs1050828	C		African variant - 10-20% activity	moderate
	rs1050829	T		African variant - mild	moderate
	rs5030868	G		Severe - <10% activity	moderate
IFNL3	rs12979860	--	Interferon/Ribavirin	Treatment response	moderate
IFNL4	rs8099917	TT	HCV antivirals	Treatment response	moderate
F5	rs6025	CC	Oral contraceptives	Factor V Leiden - clot risk	moderate
MTHFR	rs1801133	AG	Methotrexate	C677T - toxicity risk	moderate
MTHFR	rs1801131	TT	Methotrexate	A1298C - toxicity risk	moderate
CES1	rs71647871	CC	Methylphenidate, Clopidogrel	Metabolism	moderate
ABCB1	rs1045642	AG	Digoxin, Immunosuppressants	Drug transport	moderate
ABCB1	rs1128503	AA	Multiple	P-gp expression	moderate
COMT	rs4680	AG	Opioids, L-DOPA	Val158Met - pain sensitivity	moderate
OPRM1	rs1799971	AA	Opioids	A118G - reduced response	moderate
ANKK1	rs1800497	GG	Antipsychotics	Taq1A - response	moderate
SCN1A	rs3812718	TT	Carbamazepine, Phenytoin	Dose requirements	moderate
CYP2C19	rs4244285	AG	Clopidogrel, PPIs, SSRIs	*2 - non-functional	moderate
CYP2C19	rs4986893	GG	Clopidogrel	*3 - non-functional	moderate
CYP2C19	rs12248560	CC	Clopidogrel	*17 - ultra-rapid	moderate
CYP2C9	rs1799853	CC		CYP2C9*2 - S-warfarin metabolism	moderate
CYP2C9	rs1057910	AC		CYP2C9*3 - warfarin dose reduction	moderate
VKORC1	rs9923231	CC		VKORC1 - warfarin target/dose	moderate
CYP4F2	rs2108622	CT		CYP4F2 - vitamin K/warfarin dose	moderate
GGCX	rs11676382	CC		Gamma-carboxylase - warfarin response	moderate
CALU	rs339097	AA		Calumenin - warfarin sensitivity	moderate
BCHE	rs1799807	TT		BChE atypical - succinylcholine apnea	moderate
BCHE	rs1803274	CC		BChE K-variant - prolonged paralysis	moderate
CYP2B6	rs3745274	GG		CYP2B6*6 - propofol/ketamine metabolism	moderate
OPRM1	rs1799971	AA		Mu-opioid receptor - anesthetic dosing	moderate
SCN9A	rs6746030	GG		Nav1.7 - pain perception/anesthesia	moderate
TPMT	rs1800460	CC		TPMT*3B - thiopurine toxicity	moderate
TPMT	rs1142345	TT		TPMT*3C - thiopurine toxicity	moderate
CYP3A5	rs776746	CT		CYP3A5*3 - tacrolimus/chemo	moderate
ABCB1	rs1045642	AG		MDR1 - drug efflux/multidrug resistance	moderate
ABCB1	rs1128503	AA		MDR1 - drug transport	moderate
ABCG2	rs2231142	GG		ABCG2 - methotrexate clearance	moderate
GSTP1	rs1695	AA		GSTP1 - platinum drug metabolism	moderate
XRCC1	rs25487	CC		XRCC1 - alkylating agent response	moderate
SLCO1B1	rs4149056	TT		SLCO1B1 - methotrexate/statin transport	moderate
CDA	rs2072671	AA		CDA - gemcitabine toxicity	moderate
CYP2C8	rs10509681	TT		CYP2C8*3 - paclitaxel/pioglitazone	moderate
CYP1A2	rs762551	AA		CYP1A2*1F - caffeine/clozapine	moderate
UGT2B15	rs1902023	CC		UGT2B15 - lorazepam/oxazepam	moderate
GGCX		CC		Gamma-carboxylase - warfarin response	moderate
CDA		AA		CDA - gemcitabine toxicity	moderate
	rs3918290	CC	CONTRAINDICATED	*2A (IVS14+1G>A)	fatal
	rs1801265	AA	monitor	C29R	low
	rs1801159	TT	monitor	I543V	low
	rs17376848	AA	monitor	S534N	low
	rs1801158	CC	monitor	S534N variant	low

All Polygenic Risk Scores (Raw)

13 conditions with computed risk percentiles

Disease	Percentile	Risk Category	PGS ID	Matched Variants	Z-Score
depression	100.0%	High	PGS000297	914	15.472938599999999
cad	100.0%	High	PGS000018	178152	7.578375480577
t2d	99.9%	High	PGS000014	505702	3.217392059501574
afib	97.7%	High	PGS000016	505306	1.9872655253002498
prostate_cancer	96.0%	High	PGS000662	26	1.75436629
schizophrenia	86.5%	Elevated	PGS000052	43	1.105318469
breast_cancer	76.7%	Elevated	PGS000004	37	0.7300000000000001
stroke	61.2%	Average	PGS000039	305729	0.2853668992798
lung_cancer	55.8%	Average	PGS000070	3	0.145
parkinsons	49.7%	Average	PGS000089	934	-0.008269367341284292
colorectal_cancer	34.2%	Average	PGS000055	39	-0.40831933196716275
rheumatoid_arthritis	N/A	Insufficient Data	PGS000024	--	--
asthma	N/A	Insufficient Data	PGS000019	--	--

Data provenance: Variants called from consumer genotyping array (GRCh37). Risk allele counts reflect genotype comparison against reference alleles. Severity classifications are derived from published clinical significance databases (ClinVar, PharmGKB, CPIC). This data is not a substitute for clinical-grade genetic testing.

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Evening

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